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Comparative analysis of the complete genome sequence of the plant growth–promoting bacterium Bacillus amyloliquefaciens FZB42
The B. amyloliquefaciens FZB42 genome reveals an unexpected potential to produce secondary metabolites, including the polyketides bacillaene and difficidin, and identifies four giant gene clusters absent in B. subtilis 168. Expand
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. TheExpand
Characterization of the N-acetylglucosaminyltransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharide intercellular adhesin.
Results indicate a close interaction between IcaA, IcaD, and IcaC, a novel protein combination among beta-glycosyltransferases in the cytoplasmic membrane. Expand
Isolation, Structure Elucidation, and Synthesis of a Macrophage Stimulatory Lipopeptide from Mycoplasma fermentans Acting at Picomolar Concentration
Two mycoplasma-derived lipopeptides showed an identical dose dependency with a half-maximal response at 10−11 M concentration, suggesting MALP-2 may be one of the most potent natural macrophage stimulators besides endotoxin. Expand
Characterization of theN-Acetylglucosaminyltransferase Activity Involved in the Biosynthesis of the Staphylococcus epidermidisPolysaccharide Intercellular Adhesin*
Results indicate a close interaction between IcaA, IcaD, and IcaC, which represents a novel protein combination among β-glycosyltransferases and N-Acetylglucosamine oligomers produced by IcaAD. Expand
Genome analysis of Bacillus amyloliquefaciens FZB42 reveals its potential for biocontrol of plant pathogens.
The genome of plant-associated Bacillus amyloliquefaciens FZB42 harbors an array of giant gene clusters involved in synthesis of lipopeptides and polyketides with antifungal, antibacterial and nematocidal activity and genes involved in ribosome-dependent synthesis of lantibiotics and other peptides are scarce. Expand
Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in Bacillus amyloliquefaciens FZB 42
Cassette mutagenesis combined with advanced mass spectrometric techniques revealed that the pks1 (bae) and pks3 (dif) gene clusters encode the biosynthesis of the polyene antibiotics bacillaene and difficid in or oxydifficidin, respectively. Expand
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.
The halogenase gene could be overexpressed in Pseudomonas fluorescens BL915 DeltaORF1 and was purified to homogeneity by immobilized metal chelate ion affinity chromatography. Expand
Identification and Analysis of the Balhimycin Biosynthetic Gene Cluster and Its Use for Manipulating Glycopeptide Biosynthesis in Amycolatopsis mediterranei DSM5908
Structural analysis by high-performance liquid chromatography–mass spectrometry, fragmentation studies, and amino acid analysis demonstrated that these oxygenases are involved in the coupling of the aromatic side chains of the unusual heptapeptide. Expand
The structure of salmochelins: C-glucosylated enterobactins of Salmonella enterica§
A detailed analysis proved iroB to be the sole gene with glycosyltransferase activity necessary for salmochelin production and comparison of partial structures of salmochelins with a C-glycosylated compound previously characterized by another group strongly suggest that salmOChelins represent the long sought compounds termed Salmonella resistance factors (SRF) or pacifarins. Expand