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Dihydrofolate synthase

Known as: dihydrofolate synthetase 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

peptide synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial… Expand
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Highly Cited
2013
Highly Cited
2013
para-Aminosalicylic Acid Is a Prodrug Targeting Dihydrofolate Reductase in Mycobacterium tuberculosis♦
Background: PAS is an antimycobacterial whose mechanism(s) of action remains elusive. Results: PAS is incorporated into the… Expand
2010
2010
Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition
Graphical abstract The activities of the bifunctional folate pathway enzyme dihydrofolate synthase–folylpolyglutamate synthase… Expand
2003
2003
The GLOBULAR ARREST1 gene, which is involved in the biosynthesis of folates, is essential for embryogenesis in Arabidopsis thaliana.
We identified a mutation in Arabidopsis that resulted in defective embryos, and we designated this mutation globular arrest1… Expand
Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate biosynthesis in plants: Molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… Expand
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2001
2001
A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria.
Folate metabolism in the human malaria parasite Plasmodium falciparum is an essential activity for cell growth and replication… Expand
1995
1995
Isolation of dihydrofolate and folylpolyglutamate synthetase activities from Neurospora.
The possible association of dihydrofolate synthetase (DHFS) and folylpolyglutamate synthetase (FPGS) in Neurospora crassa (FGSC… Expand
1988
1988
Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates.
The transfer of 17O and/or 18O from (COOH-17O or -18O) enriched substrates to inorganic phosphate (Pi) has been demonstrated for… Expand
Highly Cited
1987
Highly Cited
1987
Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene.
The nucleotide sequence of the gene for folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase (folC) has been determined… Expand
Highly Cited
1979
Highly Cited
1979
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase.
Sulfonamides are known to compete with p-aminobenzoic acid for dihydropteroate synthase. Others have reported that some… Expand
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