Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Dihydrofolate synthase

Known as: dihydrofolate synthetase 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

peptide synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.
para-Aminosalicylic acid (PAS) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis… Expand
Is this relevant?
2010
2010
Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition
Graphical abstract The activities of the bifunctional folate pathway enzyme dihydrofolate synthase–folylpolyglutamate synthase… Expand
Is this relevant?
2003
2003
The GLOBULAR ARREST1 gene, which is involved in the biosynthesis of folates, is essential for embryogenesis in Arabidopsis thaliana.
We identified a mutation in Arabidopsis that resulted in defective embryos, and we designated this mutation globular arrest1… Expand
Is this relevant?
2003
2003
Inhibition studies of sulfonamide-containing folate analogs in yeast.
In the folate biosynthetic pathway, sulfa drugs (sulfonamides and sulfones) compete with the natural substrate, para… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana.
Tetrahydrofolate coenzymes involved in one-carbon (C1) metabolism are polyglutamylated. In organisms that synthesize… Expand
Is this relevant?
2001
2001
A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria.
Folate metabolism in the human malaria parasite Plasmodium falciparum is an essential activity for cell growth and replication… Expand
Is this relevant?
1995
1995
Isolation of dihydrofolate and folylpolyglutamate synthetase activities from Neurospora.
The possible association of dihydrofolate synthetase (DHFS) and folylpolyglutamate synthetase (FPGS) in Neurospora crassa (FGSC… Expand
Is this relevant?
1987
1987
Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene.
The nucleotide sequence of the gene for folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase (folC) has been determined… Expand
Is this relevant?
1984
1984
Characterization and inhibition of dihydrofolate synthetase from Neisseria gonorrhoeae
SummaryDihydrofolate synthetase (EC 6.3.2.12) from N. gonorrhoeae was isolated and enzyme characteristics were determined. The… Expand
  • table 1
  • figure I
  • figure 2
  • figure 4
  • table 2
Is this relevant?
1979
1979
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase.
Sulfonamides are known to compete with p-aminobenzoic acid for dihydropteroate synthase. Others have reported that some… Expand
  • figure 1
  • figure 2
  • table II
  • table III
  • figure 3
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE