Folylpolyglutamate Synthase, Mitochondrial

Known as: EC 6.3.2.17, FPGS, Tetrahydrofolate Synthase 
Folylpolyglutamate synthase, mitochondrial (587 aa, ~65 kDa) is encoded by the human FPGS gene. This protein plays a role in the conversion of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
05101519772017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Pemetrexed (MTA) is a multitargeted antifolate with promising clinical activity in lung cancer. We exposed the small cell lung… (More)
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Highly Cited
2009
Highly Cited
2009
Gene expression studies require appropriate normalization methods. One such method uses stably expressed reference genes. Since… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE Research has examined the association of folate-dependent gene polymorphisms with methotrexate (MTX) toxicity in… (More)
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2005
2005
Thermacetogenium phaeum is a homoacetogenic bacterium that can grow on various substrates, such as pyruvate, methanol, or H2/CO2… (More)
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2004
2004
Breast cancer resistance protein (BCRP/ABCG2) is currently the only ABC transporter that exports mono- and polyglutamates of… (More)
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2003
2003
We have studied the molecular basis of drug resistance in human CCRF-CEM leukemia cells exposed to high dose intermittent pulses… (More)
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Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… (More)
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1997
1997
Cellular accumulation of methotrexate polyglutamates (MTXPGs) is recognized as an important determinant of the cytotoxicity and… (More)
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Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… (More)
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Highly Cited
1991
Highly Cited
1991
Determinants of methotrexate (MTX) resistance in cell lines resistant to short, but not continuous, MTX exposure were… (More)
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