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Folylpolyglutamate Synthase, Mitochondrial

Known as: EC 6.3.2.17, FPGS, Tetrahydrofolate Synthase 
Folylpolyglutamate synthase, mitochondrial (587 aa, ~65 kDa) is encoded by the human FPGS gene. This protein plays a role in the conversion of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Quantitative real-time PCR (qPCR) is a powerful tool to measure gene expression levels. Accurate and reproducible results are… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE Research has examined the association of folate-dependent gene polymorphisms with methotrexate (MTX) toxicity in… Expand
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Highly Cited
2008
Highly Cited
2008
Mass spectrometry technologies for measurement of cellular metabolism are opening new avenues to explore drug activity… Expand
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Highly Cited
2007
Highly Cited
2007
SummaryAim of the studymRNA expression of genes involved in the mechanism of action of pemetrexed was correlated with in vitro… Expand
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Highly Cited
2005
Highly Cited
2005
Thermacetogenium phaeum is a homoacetogenic bacterium that can grow on various substrates, such as pyruvate, methanol, or H2/CO2… Expand
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Highly Cited
2004
Highly Cited
2004
Breast cancer resistance protein (BCRP/ABCG2) is currently the only ABC transporter that exports mono- and polyglutamates of… Expand
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Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… Expand
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Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… Expand
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Review
1995
Review
1995
The enzyme, thymidylate synthase (TS) is considered an important target for the development of new anticancer agents. Moreover… Expand
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Highly Cited
1991
Highly Cited
1991
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… Expand
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