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IFI16 is an innate immune sensor for intracellular DNA
TLDR
IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses
TLDR
A central role is identified in regulating caspase-1-dependent maturation of IL-1β and IL-18, as well as pyroptosis, in response to synthetic double-stranded DNA, demonstrating the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity.
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
TLDR
Stimulator of IFN gene (STING) is identified as a direct receptor for DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling, revealing an unexpected species-specific role for STING as a receptor for an anticancer drug.
Conformational dynamics of ligand-dependent alternating access in LeuT
TLDR
The results identify structural motifs that underlie the isomerization of LeuT between outward-facing, inward-facing and occluded states and present a dynamic picture of the alternating-access mechanism of LeiT and NSSs that is different from the inferences reached from currently available structural models.
Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding
TLDR
It is found that DnaK/DnaJ stabilizes the protein in collapsed states that fold exceedingly slowly, and segmental chain release and compaction may be important in avoiding misfolding by proteins that fail to fold efficiently through spontaneous hydrophobic collapse.
Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
TLDR
These observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria via a pathway that did not involve the previously described sensors TLR9, DAI, RNA polymerase-III or IFI16/p204.
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
TLDR
Genes from all the three pathways seem to contribute to MTX response in the Indian population, however, these observations need to be replicated in an independent sample set.
Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer
TLDR
This cohort study investigates the use of longitudinal data from ultradeep sequencing of cell-free DNA in Danish patients with colorectal cancer to find out if the data can be used to improve the prognosis of these patients.
Reactive oxygen species in pulmonary vascular remodeling.
TLDR
This review will focus on the ROS generation systems, scavenger antioxidants, and oxidative stress associated alterations in vascular remodeling in pulmonary hypertension.
Btk Regulates B Cell Receptor-Mediated Antigen Processing and Presentation by Controlling Actin Cytoskeleton Dynamics in B Cells1
TLDR
This study identifies Bruton’s tyrosine kinase (Btk) as a linker connecting BCR signaling to actin dynamics and the Ag transport pathway, and shows that BCR engagement increases actin polymerization and Wiskott-Aldrich syndrome protein activation in a Btk-dependent manner.
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