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FOXO3 gene

Known as: FKHR-LIKE 1, FORKHEAD BOX O3A, FOXO3A 
This gene is involved in transcriptional regulation and apoptosis.
National Institutes of Health

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7 relations
ApoptosisFOXO3 wt AlleleFOXO3A protein, humanHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
MiR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3.
The aim of the present study was to investigate the association between microRNA (miR)-155 and apoptosis of monocytes infected by… 
Highly Cited
2015
Highly Cited
2015
Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes
The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling… 
Highly Cited
2009
Highly Cited
2009
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.
FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently been linked to human longevity in Japanese, German and… 
Highly Cited
2008
Highly Cited
2008
The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression
ABSTRACT The phosphoinositide-3 kinase (PI3K)/Akt signal pathway plays a key role in the tumorigenesis of many cancers and in the… 
Highly Cited
2007
Highly Cited
2007
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
Protein kinase-B (PKB) and its target, the forkhead transcription factor like 1 (FKHRL1)/FoxO3a, have been suggested as… 
Highly Cited
2007
Highly Cited
2007
Induction of Mxi1-SRα by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression
ABSTRACT Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase (PI3… 
Highly Cited
2006
Highly Cited
2006
RUNX3 Cooperates with FoxO3a to Induce Apoptosis in Gastric Cancer Cells*
The transcription factor RUNX3, which mediates apoptosis and cell growth inhibition in gastric epithelial cells, is a candidate… 
Highly Cited
2005
Highly Cited
2005
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell lines as model systems to investigate the… 
Review
2004
Review
2004
Human FOX gene family (Review).
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1… 
Highly Cited
1997
Highly Cited
1997
AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.
Fusion genes implicating the MLL gene have been recently demonstrated in various 11q23 chromosomal abnormalities in human… 
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