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FOXO3 gene

Known as: FKHR-LIKE 1, FORKHEAD BOX O3A, FOXO3A 
This gene is involved in transcriptional regulation and apoptosis.
National Institutes of Health

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7 relations
ApoptosisFOXO3 wt AlleleFOXO3A protein, humanHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on… 
2014
2014
SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
Silent information regulator type-1 (SIRT1) is the best-studied member of the Sirtuin (Sir2) family of nicotinamide dinucleotide… 
Highly Cited
2011
Highly Cited
2011
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg
MicroRNAs (miRNAs) play important roles in regulating post-transcriptional gene repression in a variety of immunological… 
2011
2011
A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice
An N-ethyl-N-nitrosourea random mutation screen was used to identify recessive modifiers of gene silencing in the mouse using an… 
2011
2011
Cell-Penetrating TAT-FOXO3 Fusion Proteins Induce Apoptotic Cell Death in Leukemic Cells
FOXO proteins are Akt-regulated transcription factors involved in the control of cell cycle, DNA repair, stress defense… 
2009
2009
Transcriptomic analysis identifies Foxo3A as a novel transcription factor regulating mesenchymal stem cell chrondrogenic differentiation.
Multipotent mesenchymal stromal cells (MSC) are progenitor cells able to differentiate into several lineages including… 
2006
2006
Phosphatidylinositol 3-Kinase-dependent Suppression of the Human Inducible Nitric-oxide Synthase Promoter Is Mediated by FKHRL1*
The synthesis of nitric oxide by inducible nitric-oxide synthase (iNOS) plays an important role in the innate immune response by… 
Highly Cited
2004
Highly Cited
2004
Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin.
The Forkhead family transcription factor FKHRL1 is an inducer of apoptosis in its unphosphorylated form and was recently reported… 
2004
2004
Expression and intracellular localization of FKHRL1 in mammary gland neoplasms.
FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors… 
2002
2002
Insulin-Like Growth Factor-1 – Induced Phosphorylation of Transcription Factor FKHRL 1 Is Mediated by Phosphatidylinositol 3-Kinase / Akt Kinase and Role of This Pathway in Insulin-Like Growth Factor…
Insulin-like growth factor-1 (IGF-1) is a trophic factor promoting cell survival by activating phosphatidylinositol 3-kinase… 
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