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Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial…
Based on data, NSIP should be separated into cellular and fibrosing patterns, because these histologic patterns are associated with different clinical characteristics and prognoses.
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
- R. Premont, A. Claing, R. Lefkowitz
- Biology, Computer ScienceProceedings of the National Academy of Sciences…
- 24 November 1998
An essential role for ARF proteins in regulating beta2-adrenergic receptor endocytosis is suggested through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane.
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
SIRT1 can be directly activated through an allosteric mechanism common to chemically diverse STACs, and specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate Sirtuin-activating compounds (STACs) activation by STacs.
Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
In patients with LAM, sirolimus stabilized lung function, reduced serum VEGF-D levels, and was associated with a reduction in symptoms and improvement in quality of life.
Molecules in the ARF Orbit*
Criteria for designation as an ARF have been the ability to activate cholera toxin and to rescue mutant Saccharomyces cerevisiae bearing the lethal double deletion of ARF1 and ARF2 genes.
The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment.
The age range of women afflicted with pulmonary lymphangioleiomyomatosis is broader than previously appreciated and the degree of pulmonary function can be quite variable, with one-third of subjects having normal spirometry at enrollment into this registry.
Identification and Characterization of a Mammalian 39-kDa Poly(ADP-ribose) Glycohydrolase*
The identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity but is structurally unrelated to PARG, but did not hydrolyze ADP- ribose-arginine,-cysteine, -diphthamide, or -asparagine bonds.
Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis.
Improved diagnostic methods have defined the abnormalities in patients with pulmonary LAM and increased the potential for early recognition and treatment of this disorder.
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
The agonists-driven formation of a complex including beta-arrestin, ARNO, and ARF6 provides a molecular mechanism that explains how the agonist-stimulated receptor recruits a small G protein necessary for the endocytic process and controls its activation.
GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6*
- N. Vitale, W. Patton, J. Moss, M. Vaughan, R. Lefkowitz, R. Premont
- Biology, Computer ScienceThe Journal of Biological Chemistry
- 5 May 2000
The results suggest that although the mechanism of GTP hydrolysis is probably very similar in these two families of ARF GAPs, GIT proteins might specifically regulate the activity of ARf6 in cells in coordination with phosphatidylinositol 3-kinase signaling pathways.