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FOXO3 wt Allele

Known as: FKHRL1, Forkhead Box O3 wt Allele, FOXO3 
Human FOXO3 wild-type allele is located in the vicinity of 6q21 and is approximately 121 kb in length. This allele, which encodes forkhead box… Expand
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Skeletal muscle mass increases during postnatal development through a process of hypertrophy, i.e. enlargement of individual… Expand
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Highly Cited
2009
Highly Cited
2009
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which… Expand
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Highly Cited
2009
Highly Cited
2009
The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway… Expand
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Highly Cited
2009
Highly Cited
2009
In the nervous system, neural stem cells (NSCs) are necessary for the generation of new neurons and for cognitive function. Here… Expand
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Highly Cited
2009
Highly Cited
2009
FOXO (Forkhead box O) transcription factors induce cell growth arrest and apoptosis, which can be prevented by FOXO… Expand
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Highly Cited
2007
Highly Cited
2007
Autophagy allows cell survival during starvation through the bulk degradation of proteins and organelles by lysosomal enzymes… Expand
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Highly Cited
2007
Highly Cited
2007
Muscle atrophy occurs in many pathological states and results primarily from accelerated protein degradation and activation of… Expand
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Highly Cited
2007
Highly Cited
2007
The maintenance of homeostasis throughout an organism's life span requires constant adaptation to changes in energy levels. The… Expand
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Highly Cited
2006
Highly Cited
2006
Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the… Expand
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Highly Cited
2004
Highly Cited
2004
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases… Expand
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