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FOXO3 wt Allele

Known as: FKHRL1, Forkhead Box O3 wt Allele, FOXO3 
Human FOXO3 wild-type allele is located in the vicinity of 6q21 and is approximately 121 kb in length. This allele, which encodes forkhead box… 
National Institutes of Health

Related topics

Related topics

11 relations
6q21AKT Signaling PathwayApoptosisFOXO3 gene

Papers overview

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Highly Cited
2015
Highly Cited
2015
The life-extending effect of dietary restriction requires Foxo3 in mice
Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study… 
Highly Cited
2013
Highly Cited
2013
SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth*
Background: SIRT1 regulates the activity of FoxO transcription factors and protects tissues from diverse insults. Results: Upon… 
Highly Cited
2012
Highly Cited
2012
A FOXO3/IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1… 
Highly Cited
2012
Highly Cited
2012
Glioma‐Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK
Control of the cancer stem/initiating cell population is considered key to realizing the long‐term survival of glioblastoma… 
Highly Cited
2008
Highly Cited
2008
Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells*
Unchecked accumulation of reactive oxygen species (ROS) compromises maintenance of hematopoietic stem cells. Regulation of ROS by… 
Highly Cited
2008
Highly Cited
2008
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
The rapid loss of muscle mass, which occurs with disuse and systemically with fasting, cancer and many other diseases, results… 
Highly Cited
2007
Highly Cited
2007
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway… 
Highly Cited
2007
Highly Cited
2007
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
Protein kinase-B (PKB) and its target, the forkhead transcription factor like 1 (FKHRL1)/FoxO3a, have been suggested as… 
Highly Cited
2006
Highly Cited
2006
RUNX3 Cooperates with FoxO3a to Induce Apoptosis in Gastric Cancer Cells*
The transcription factor RUNX3, which mediates apoptosis and cell growth inhibition in gastric epithelial cells, is a candidate… 
Review
2001
Review
2001
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
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