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FOXO3 wt Allele

Known as: FKHRL1, Forkhead Box O3 wt Allele, FOXO3 
Human FOXO3 wild-type allele is located in the vicinity of 6q21 and is approximately 121 kb in length. This allele, which encodes forkhead box… 
National Institutes of Health

Related topics

Related topics

11 relations
6q21AKT Signaling PathwayApoptosisFOXO3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development.
2013
2013
FOXO 3 Shares Common Targets with ASCL 1 Genome-wide and Inhibits ASCL 1-Dependent Neurogenesis
Ashley E. Webb,1 Elizabeth A. Pollina,1,2 Thomas Vierbuchen,2,3,8,10 Noelia Urbán,7,8 Duygu Ucar,1,8 Dena S. Leeman,1,2,8 Ben… 
Highly Cited
2012
Highly Cited
2012
FOXO3 gene variants and human aging: coding variants may not be key players.
FOXO3 is generally recognized as a "master" gene in aging since its association with longevity has been replicated in multiple… 
2012
2012
Histone Deacetylation Inhibition in Pulmonary HypertensionClinical Perspective
Background— Epigenetic programming, dynamically regulated by histone acetylation, is a key mechanism regulating cell… 
2011
2011
FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide.
BACKGROUND Overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has emerged as a pivotal trigger of thyroid… 
Highly Cited
2009
Highly Cited
2009
Runx1 Is a Co-activator with FOXO3 to Mediate Transforming Growth Factor β (TGFβ)-induced Bim Transcription in Hepatic Cells*
Transforming growth factor β (TGFβ) regulates essential cellular functions such as cellular proliferation, differentiation, and… 
Review
2009
Review
2009
Pathophysiological relevance of forkhead transcription factors in brain ischemia.
Forkhead box transcription factor, class 0 (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of… 
2005
2005
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.
Papillary thyroid carcinoma (PTC) is a heterogenous disorder characterized by unique gene rearrangements and gene mutations that… 
Highly Cited
2004
Highly Cited
2004
Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin.
The Forkhead family transcription factor FKHRL1 is an inducer of apoptosis in its unphosphorylated form and was recently reported… 
2004
2004
Expression and intracellular localization of FKHRL1 in mammary gland neoplasms.
FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors… 
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