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FOXO Family

Known as: Fork Head Box Transcription Factor Class O, Forkhead Box Transcription Factor Class O, FoxO 
A subfamily within the forkhead box (FOX) protein family, which is a family of transcription factors that contain a forkhead DNA-binding domain. FOXO… 
National Institutes of Health

Related topics

Related topics

7 relations
FOXO1A protein, humanFOXO3A protein, humanForkhead BoxForkhead Box Protein O4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
microRNA-499-5 p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO 4 and PDCD 4
MicroRNAs (miRNAs) regulate tumor progression and invasion via direct interaction with target messenger RNAs (mRNAs). We defined… 
Highly Cited
2009
Highly Cited
2009
FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue
OBJECTIVE Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating… 
Review
2009
Review
2009
FoxO proteins: cunning concepts and considerations for the cardiovascular system.
Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer… 
Review
2009
Review
2009
The "O" class: crafting clinical care with FoxO transcription factors.
Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel… 
Highly Cited
2009
Highly Cited
2009
Morphogenesis of Strongyloides stercoralis Infective Larvae Requires the DAF-16 Ortholog FKTF-1
Based on metabolic and morphological similarities between infective third-stage larvae of parasitic nematodes and dauer larvae of… 
Review
2007
Review
2007
Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress.
Several protective cellular mechanisms protect against the accumulation of reactive oxygen species (ROS) and the concomitant… 
Highly Cited
2007
Highly Cited
2007
Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin.
Highly Cited
2006
Highly Cited
2006
RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells.
Breast cancer is one of the most common malignancies affecting women in the Western world and one in seven women is predicted to… 
Review
2005
Review
2005
Transcriptional regulation of neuronal genes and its effect on neural functions: expression and function of forkhead transcription factors in neurons.
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of… 
Highly Cited
2005
Highly Cited
2005
Aging and longevity: the IGF-1 enigma.
See related article, pages 418–426 IGF-1 belongs to the insulin family of peptides and acts as a growth factor in many tissues… 
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