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Forkhead Box Protein O4

Known as: Trithorax Homolog 7, MLLT7, FOXO4 
Forkhead box protein O4 (505 aa, ~54 kDa) is encoded by the human FOXO4 gene. This protein plays a role in cell cycle arrest, transcriptional… Expand
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
Forkhead transcription factors of the FOXO class are negatively regulated by PKB/c‐Akt in response to insulin/IGF signalling, and… Expand
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Highly Cited
2004
Highly Cited
2004
Genetic analysis in Caenorhabditis elegans has uncovered essential roles for DAF-16 in longevity, metabolism, and reproduction… Expand
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Review
2002
Review
2002
The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a) and AFX (FOXO4), are regulated by the… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT The FoxO forkhead transcription factors FoxO4 (AFX), FoxO3a (FKHR.L1), and FoxO1a (FKHR) represent important… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-kinase (PI3K)/protein kinase B… Expand
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Highly Cited
2002
Highly Cited
2002
The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell… Expand
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Highly Cited
2000
Highly Cited
2000
The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in… Expand
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Highly Cited
2000
Highly Cited
2000
daf-16 is a forkhead-type transcription factor, functioning downstream of insulin-like signals, and is known to be critical to… Expand
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Highly Cited
1999
Highly Cited
1999
The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B (refs 1, 2) regulates certain insulin-responsive genes… Expand
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Highly Cited
1997
Highly Cited
1997
In mammals, insulin signalling regulates glucose transport together with the expression and activity of various metabolic enzymes… Expand
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