• Publications
  • Influence
Strongyloides spp.
  • M. Viney, J. Lok
  • Medicine
    WormBook : the online review of C. elegans…
  • 2007
TLDR
The biology of Strongyloides is introduced, especially the fascinating, but complex, life-cycle together with an overview of the taxonomy, morphology, genetics and genomics of this genus.
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
TLDR
The results reveal the molecular basis for DAF-12 ligand binding and identify nuclear receptors as unique therapeutic targets in parasitic nematodes, indicating the potential use of Daf- 12 ligands to treat disseminated strongyloidiasis.
Different but overlapping populations of Strongyloides stercoralis in dogs and humans—Dogs as a possible source for zoonotic strongyloidiasis
TLDR
In dogs, the results show that dogs carry two populations, possibly different species of Strongyloides, which argues for the strong potential of dogs as reservoirs for zoonotic transmission of S. stercoralis to humans and suggests that in order to reduce the exposure of humans to infective S.Stercorais larvae, dogs should be treated for the infection along with their owners.
Strongyloides stercoralis: a model for translational research on parasitic nematode biology.
  • J. Lok
  • Biology, Medicine
    WormBook : the online review of C. elegans…
  • 17 February 2007
TLDR
A practical method for transient transformation of S. stercoralis with vector constructs having various tissue- and cell-specific expression patterns and assembled these into a modular vector kit for distribution to the community is developed.
Transposon-mediated Chromosomal Integration of Transgenes in the Parasitic Nematode Strongyloides ratti and Establishment of Stable Transgenic Lines
TLDR
This work constructed a donor vector encoding green fluorescent protein (GFP) under the control of the Ss-act-2 promoter with flanking inverted tandem repeats specific for the piggyBac transposon that provides the basis for two powerful functional genomic tools in S. ratti: heritable transgenesis and insertional mutagenesis.
Strongyloides stercoralis: Amphidial neuron pair ASJ triggers significant resumption of development by infective larvae under host-mimicking in vitro conditions.
TLDR
Based on the developmental neurobiology of C. elegans, resumption of development by S. stercoralis L3i should be mediated, in part at least, by neurons homologous to the ASJ pair of C., and this hypothesis was tested by ablation of ASJ neurons in S.Stercorais first-stage larvae.
The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes
TLDR
Exploiting the unique Strongyloides life cycle, the transcriptomes of the parasitic and free-living stages are compared and it is found that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis.
TLDR
It is demonstrated that S. stercoralis larvae trigger the release of ETs by human neutrophils and macrophages, which ensnare the parasite facilitating larval killing by cells of the immune system.
Macrocyclic lactones in the treatment and control of parasitism in small companion animals.
  • T. Nolan, J. Lok
  • Biology, Medicine
    Current pharmaceutical biotechnology
  • 1 May 2012
TLDR
Macrocyclic lactones as a group have intrinsic insecticidal and acaricidal activity, and topical or otic formulations of certain compounds are approved for treatment and control of fleas, certain ixodid ticks, sarcoptiform and demodectic mange mites and psoroptiform ear mites.
Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida).
TLDR
It is concluded from experiments that the fork head transcription factor DAF-16 and, by inference, other insulin-like signalling elements, are conserved in H. contortus, a parasitic nematode of paramount economic importance.
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