FHA Domain

Known as: Forkhead-Associated Domain 
The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for… (More)
National Institutes of Health

Related topics

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4 relations
AfadinCHEK2 protein, humanKi-67 AntigenNBS1 protein, human

Papers overview

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2009
2009
An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.
Forkhead-associated (FHA) domains have gained considerable prominence as ubiquitous phosphothreonine-dependent binding modules… (More)
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Highly Cited
2007
Highly Cited
2007
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints… (More)
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Highly Cited
2007
Highly Cited
2007
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
Accumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of… (More)
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Highly Cited
2007
Highly Cited
2007
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding… (More)
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2005
2005
Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67
The forkhead-associated (FHA) domain of human Ki67 interacts with the human nucleolar protein hNIFK, recognizing a 44-residue… (More)
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Highly Cited
2003
Highly Cited
2003
MDC1 is required for the intra-S-phase DNA damage checkpoint
MRE11, RAD50 and NBS1 form a highly conserved protein complex (the MRE11 complex) that is involved in the detection, signalling… (More)
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Highly Cited
2002
Highly Cited
2002
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
The Chk2 Ser/Thr kinase plays crucial, evolutionarily conserved roles in cellular responses to DNA damage. Identification of two… (More)
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Review
2000
Review
2000
The FHA domain mediates phosphoprotein interactions.
The forkhead-associated (FHA) domain is a phosphopeptide-binding domain first identified in a group of forkhead transcription… (More)
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Highly Cited
1999
Highly Cited
1999
The FHA domain is a modular phosphopeptide recognition motif.
FHA domains are conserved sequences of 65-100 amino acid residues found principally within eukaryotic nuclear proteins, but which… (More)
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Highly Cited
1998
Highly Cited
1998
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.
The Rad53 protein kinase of Saccharomyces cerevisiae is required for checkpoints that prevent cell division in cells with damaged… (More)
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