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FHA Domain

Known as: Forkhead-Associated Domain 
The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for… 
National Institutes of Health

Related topics

Related topics

4 relations
AfadinCHEK2 protein, humanKi-67 AntigenNBS1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions
Phosphoprotein recognition directs kinase-phosphatase interactions at multiple levels in the mammalian Hippo pathway. Switching… 
Highly Cited
2008
Highly Cited
2008
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
The MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in… 
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Highly Cited
2007
Highly Cited
2007
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding… 
Highly Cited
2007
Highly Cited
2007
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
Accumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of… 
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Highly Cited
2007
Highly Cited
2007
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints… 
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Review
2006
Review
2006
IκB kinase complexes: gateways to NF-κB activation and transcription
Transcription factors of the NF-κB family regulate hundreds of genes in the context of multiple important physiological and… 
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Highly Cited
2004
Highly Cited
2004
Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1
Regulation of ribosome biogenesis is central to the control of cell growth. In rapidly growing yeast cells, ribosomal protein (RP… 
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Highly Cited
2002
Highly Cited
2002
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
The Chk2 Ser/Thr kinase plays crucial, evolutionarily conserved roles in cellular responses to DNA damage. Identification of two… 
Highly Cited
1999
Highly Cited
1999
The FHA domain is a modular phosphopeptide recognition motif.
FHA domains are conserved sequences of 65-100 amino acid residues found principally within eukaryotic nuclear proteins, but which… 
Highly Cited
1998
Highly Cited
1998
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.
The Rad53 protein kinase of Saccharomyces cerevisiae is required for checkpoints that prevent cell division in cells with damaged… 
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