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Afadin

Known as: Trithorax Homolog 4, AF-6 Protein, AF6 
Afadin (1824 aa, ~207 kDa) is encoded by the human MLLT4 gene. This protein is involved in both cell communication and the formation of adherens… 
National Institutes of Health

Related topics

Related topics

18 relations
Actin-Binding ProteinCell MovementCell-Cell Adhesion ProcessCytokinesis

Broader (1)

Microfilament Proteins

Narrower (1)

lafadin

Papers overview

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2012
2012
The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain
Electrical synapses formed by neuronal gap junctions composed of connexin36 (Cx36) occur in most major structures in the… 
2012
2012
Afadin Is Required for Maintenance of Dendritic Structure and Excitatory Tone*
Background: Active molecular mechanisms that maintain the dendritic field of neurons are unclear. Results: Afadin maintains… 
2011
2011
The dominant 55 kDa allergen of the subtropical Bahia grass (Paspalum notatum) pollen is a group 13 pollen allergen, Pas n 13.
2007
2007
AF6/s‐afadin is a dual residency protein and localizes to a novel subnuclear compartment
The AF6/afadin protein is a component of cell membranes at specialized sites of cell–cell contact. Two main splice variants exist… 
Highly Cited
2005
Highly Cited
2005
AF6 Negatively Regulates Rap1-induced Cell Adhesion*
AF6 is involved in the connection of membrane-associated proteins to the actin cytoskeleton. It binds to Ras-like small GTPases… 
2003
2003
ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.
Afadin is an actin filament (F-actin)-binding protein that is associated with the cytoplasmic tail of nectin, a Ca(2… 
2002
2002
Mosaic structure and retropositional dynamics during evolution of subfamilies of short interspersed elements in African cichlids.
The African cichlid (AFC) family of short interspersed elements (SINEs) is found in the genomes of cichlid fish. The alignment of… 
1998
1998
A region of conformational variability outside the peptide-binding site of a class I MHC molecule.
Peptide binding is known to influence the conformation of the surface of class I molecules as detected with mAbs and TCR. A new… 
1997
1997
Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus
In infantile leukemias and therapy-related leukemias, the MLL gene is frequently found to be disrupted and fused to various… 
1983
1983
Triggering of monoclonal human lymphoma B cells with antibodies to IgM heavy chains: differences of response obtained with monoclonal as compared to polyclonal antibodies.
A comparative study of human B lymphoma cells activation by monoclonal (murine hybridoma) antibodies to mu heavy chains (Ma-mu… 
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