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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
It is suggested that the Rad51 protein, probably together with Rad52 protein, is involved in a step to convert DSBs to the next intermediate in recombination. Expand
Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
Observations provide the first genetic evidence that both repair pathways play a role in maintaining chromosomal DNA during the cell cycle. Expand
Rapid Telomere Movement in Meiotic Prophase Is Promoted By NDJ1, MPS3, and CSM4 and Is Modulated by Recombination
Haploidization of the genome in meiosis requires that chromosomes be sorted exclusively into pairs stabilized by synaptonemal complexes (SCs) and crossovers. This sorting and pairing is accompaniedExpand
Rad51‐deficient vertebrate cells accumulate chromosomal breaks prior to cell death
  • E. Sonoda, M. Sasaki, +6 authors Shunichi Takeda
  • Biology, Medicine
  • The EMBO journal
  • 15 January 1998
Chromosome analysis revealed that most metaphase‐arrested Rad51− cells carried isochromatid‐type breaks, indicating that Rad51 fulfils an essential role in the repair of spontaneously occurring chromosome breaks in proliferating cells of higher eukaryotes. Expand
Rad52 forms ring structures and co‐operates with RPA in single‐strand DNA annealing
The RAD52 epistasis group in Saccharomyces cerevisiae is involved in various types of homologous recombination including recombinational double‐strand break (DSB) repair and meiotic recombination. AExpand
Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis.
One of the differences between the late stages of mitotic recombination and meiotic recombination might be specified by differential dependency on the Rad54 and Rdh54/Tid1 proteins. Expand
Similarity of the yeast RAD51 filament to the bacterial RecA filament.
The RAD51 protein functions in the processes of DNA repair and in mitotic and meiotic genetic recombination in the yeast Saccharomyces cerevisiae. The protein has adenosine triphosphate-dependent DNAExpand
Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
Rad51 and Dmc1 are Saccharomyces cerevisiae homologues of the Escherichia coli recombination protein RecA. Mutant analysis has shown that both proteins are required for normal meiotic recombination,Expand
Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
The rad51 homologues fail to complement the DNA repair defect of rad51 mutants of S. cerevisiae, and the 339 amino acid proteins predicted for the two mammalian genes are almost identical and are highly homologous (83%) with the yeast proteins. Expand
Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes.
We show that the Saccharomyces cerevisiae recombination protein Rad52 and the single-strand DNA-binding protein RPA assemble into cytologically detectable subnuclear complexes (foci) during meioticExpand