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FANFT

Known as: Formamide, N-(4-(5-nitro-2-furanyl)-2-thiazolyl)-, FANFT [Chemical/Ingredient], formamidonitrofurylthiazole 
A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.
National Institutes of Health

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Related topics

6 relations

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ANFT

Broader (1)

Thiazoles
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2005
2005
Biological effects of shock waves
SummaryExtracorporeal shock wave lithotripsy has become established worldwide as the method of choice for the treatment of… Expand
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Highly Cited
1992
Highly Cited
1992
Acrolein initiates rat urinary bladder carcinogenesis.
Acrolein, a reactive, alpha,beta-unsaturated aldehyde which is ubiquitous in the environment, forms DNA adducts, is mutagenic… Expand
Highly Cited
1984
Highly Cited
1984
A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.
A theoretical model of two-stage carcinogenesis has been hypothesized. Variables that are modeled include the populations of… Expand
1980
1980
Effects of urine and continued exposure to carcinogen on progression of early neoplastic urinary bladder lesions.
Based on reports of regression of superficial bladder tumors after urinary diversion, a study was designed to measure the effects… Expand
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Highly Cited
1979
Highly Cited
1979
Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis.
The existence of at least two stages in bladder carcinogenesis was evaluated in male Fischer rats using N-[14-(5-nitro-2-furyl)-2… Expand
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Highly Cited
1979
Highly Cited
1979
The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.
A comparison of two rapid and inexpensive in vivo mammalian assays and the Ames Salmonella assay is presented for 61 agents… Expand
Highly Cited
1977
Highly Cited
1977
Malignant transformation of urinary bladder in humans and in N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-exposed Fischer rats: ultrastructure of the major components of the permeability barrier.
Summary Normal urinary bladder transitional epithelium (urothelium) contains a permeability barrier to water and solutes… Expand
Review
1977
Review
1977
Intravesical and systemic chemotherapy of murine bladder cancer.
Summary Transitional cell carcinomas induced in syngeneic mice by the carcinogen N -[4-(5-nitro-2-furyl)-2-thiazolyl]formamide… Expand
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Highly Cited
1977
Highly Cited
1977
Cytotoxicity and DNA damage to mammalian cells by nitrofurans.
Nitrofurazone, nitrofurantoin, furazolidone, furaltadone and N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) were toxic to… Expand
Highly Cited
1974
Highly Cited
1974
On the mutagenicity of nitrofurans.
Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp… Expand
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