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Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
DMA was demonstrated to be a carcinogen for the rat urinary bladder and suggested that DMA exposure may be relevant to the carcinogenic risk of inorganic arsenic in humans and diverse genetic alterations observed in DMA-induced urinary bladder tumors imply that multiple genes are involved in stages of D MA-induced tumor development. Expand
Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.
It is demonstrated that long-term p.p. o. administration of DMA induced urinary bladder carcinomas in male F344 rats, indicating that DMA is carcinogenic for the rat urinary bladder, which may be related to the human carcinogenicity of arsenicals. Expand
Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats.
Well-dispersed MWCNT brought about dose- or time-dependent changes in lung weight, total proteins, albumin, lactate dehydrogenase and alkaline phosphatase in the BAL fluid, and pulmonary lesions including inflammation, Type II cell hyperplasia, microgranulomas and fibrosis. Expand
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
It is suggested that CYP2E1 completely participates in diethylnitrosamine-induced hepatocarcinogenesis, and high frequency of tumors in wild-type mice could be associated with the increased apoptosis. Expand
Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis.
Studies were conducted on the carcinogenic activity of butylated hydroxyanisole (BHA) in rats and hamsters. To obtain information concerning the mechanism of action of BHA on the forestomach, theExpand
Evaluation of narrow-band imaging as a complementary method for the detection of bladder cancer.
NBI is a simple and effective method for identifying bladder tumors including CIS without the need for dyes because of its high sensitivity, high NPV, and low NLR. Expand
Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats
There is clear evidence that MWNT-7 is carcinogenic to the lungs of male and female F344 rats, however no plural mesothelioma was observed. Expand
Genotoxicity and Cytotoxicity of Multi‐wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers
Genotoxicity and Cytotoxicity of Multi‐wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers: Masumi Asakura, et al. Japan Bioassay Research Center,Expand
Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident.
Significant alterations in regulation of cell cycle transitions are associated with increased cell proliferation, along with up-regulated ubiquitination and sumoylation processes as well as inefficient DNA repair in the affected urothelium. Expand
Some drinking-water disinfectants and contaminants, including arsenic.
Members M.W. Anders, Richard J. Bull, Chien-Jen Chen, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, and Catterina Ferreccio. Expand