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F2RL3 gene

Known as: PROTEASE-ACTIVATED RECEPTOR 4, THROMBIN RECEPTOR-LIKE 3, F2R like thrombin/trypsin receptor 3 
This gene plays a role in both receptor signaling and platelet activation.
National Institutes of Health

Related topics

Related topics

8 relations
F2RL3 protein, humanG Protein-Coupled Receptor SignalingLigand BindingPlatelet Activation

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F2RL3 wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear‐resistance of platelet aggregates
Summary.  Background: Flow chambers allow the ex vivo study of platelet response to defined surfaces at controlled wall shear… 
Highly Cited
2007
Highly Cited
2007
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Second messenger-mediated inside-out activation of integrin alphaIIbbeta3 is a key step in platelet aggregation. We recently… 
Highly Cited
2006
Highly Cited
2006
PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation*
Regulation of platelet activation plays a central role in hemostasis and pathophysiological processes such as coronary artery… 
Highly Cited
2006
Highly Cited
2006
The Bacteroides fragilis Toxin Binds to a Specific Intestinal Epithelial Cell Receptor
ABSTRACT The Bacteroides fragilis toxin (BFT) is the only known virulence factor of enterotoxigenic B. fragilis. BFT has… 
Review
2006
Review
2006
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more
Abstract Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target… 
Highly Cited
2004
Highly Cited
2004
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… 
Highly Cited
2001
Highly Cited
2001
Protease‐Activated Receptor (PAR) 1 but Not PAR2 or PAR4 Mediates Endothelium‐Dependent Relaxation to Thrombin and Trypsin in Human Pulmonary Arteries
&NA; Endothelial protease‐activated receptors (PARs) may be important sensors of vascular inflammation and injury. Activation of… 
Highly Cited
2000
Highly Cited
2000
Protease-activated Receptors 1 and 4 Are Shut Off with Distinct Kinetics after Activation by Thrombin*
Protease-activated receptors 1 and 4 (PAR1 and PAR4) mediate thrombin signaling in human platelets. Whether these receptors are… 
Highly Cited
2000
Highly Cited
2000
Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets.
Thrombin activates platelets in an ordered sequence of events that includes shape change, increase in cytoplasmic Ca(2… 
Highly Cited
1999
Highly Cited
1999
Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.
The activation of human platelets by thrombin is mediated primarily by protease-activated receptors (PARs). PAR1 and PAR4 are… 
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