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F2RL3 gene

Known as: PROTEASE-ACTIVATED RECEPTOR 4, THROMBIN RECEPTOR-LIKE 3, F2R like thrombin/trypsin receptor 3 
This gene plays a role in both receptor signaling and platelet activation.
National Institutes of Health

Related topics

Related topics

8 relations
F2RL3 protein, humanG Protein-Coupled Receptor SignalingLigand BindingPlatelet Activation

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F2RL3 wt Allele

Papers overview

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2015
2015
Exposure to welding fumes is associated with hypomethylation of the F2RL3 gene: a cardiovascular disease marker
Background Welders are at risk for cardiovascular disease. Recent studies linked tobacco smoke exposure to hypomethylation of the… 
2014
2014
Protease-activated receptor (PAR)1, PAR2 and PAR4 expressions in esophageal squamous cell carcinoma.
Here, we used reverse transcription-PCR (RT-PCR) and western blot to detect protease-activated receptor (PAR) 1, PAR 2 and PAR 4… 
Highly Cited
2011
Highly Cited
2011
Protease-Activated Receptor Signaling in Platelets Activates Cytosolic Phospholipase A2&agr; Differently for Cyclooxygenase-1 and 12-Lipoxygenase Catalysis
Objective—The rate-limiting step in the biosynthesis of thromboxane A2 (TxA2) and 12-hydroxyeicosatetraenoic acid (12-HETE) by… 
2011
2011
Induction of apoptosis by thrombin in the cultured neurons of dorsal motor nucleus of the vagus
Background  A previous study demonstrated the presence of protease‐activated receptor (PAR) 1 and 2 in the dorsal motor nucleus… 
2009
2009
Suboptimal Activation of Protease-activated Receptors Enhances α2β1 Integrin-mediated Platelet Adhesion to Collagen*
Thrombin and fibrillar collagen are potent activators of platelets at sites of vascular injury. Both agonists cause platelet… 
2007
2007
Distinct Ca 2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR 1 and PAR 4 ) in vascular endothelial cells *
Proteinase-activated receptor 1 and 4 (PAR 1 and PAR 4 ) are the major receptors mediating thrombin-induced NO production in… 
2006
2006
GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules Independent of Src Kinases and Syk
Objective—The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet… 
2006
2006
Murine Thrombin Lacks Na+ Activation but Retains High Catalytic Activity*
Human thrombin utilizes Na+ as a driving force for the cleavage of substrates mediating its procoagulant, prothrombotic, and… 
2002
2002
Protease-activated receptor 4-like peptides bind to thrombin through an optimized interaction with the enzyme active site surface.
Review
2002
Review
2002
Protease-activated receptors: the role of cell-surface proteolysis in signalling.
Certain extracellular proteases, derived from the circulation and inflammatory cells, can specifically cleave and trigger… 
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