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Elacridar

 
National Institutes of Health

Papers overview

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2013
2013
Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of P-glycoprotein (Pgp) and breast… Expand
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Highly Cited
2012
Highly Cited
2012
Sunitinib is an orally active, multitargeted tyrosine kinase inhibitor which has been used for the treatment of metastatic renal… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: Imatinib, a BCR-ABL tyrosine kinase inhibitor, is a substrate of the efflux transporters P-glycoprotein (P-gp; ABCB1… Expand
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Highly Cited
2009
Highly Cited
2009
PurposeOveractivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to… Expand
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2009
2009
With the aim to develop a positron emission tomography (PET) tracer to assess the distribution of P-glycoprotein (P-gp) at the… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: Breast cancer resistance protein (ABCG2) substantially limits the oral bioavailability of topotecan. Coadministration… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of… Expand
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Highly Cited
2006
Highly Cited
2006
Multidrug-resistant (MDR) cancer may be treated using combinations of encapsulated cytotoxic drugs and chemosensitizers. To… Expand
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Highly Cited
2005
Highly Cited
2005
Imatinib mesylate (signal transduction inhibitor 571, Gleevec) is a potent and selective tyrosine kinase inhibitor, which was… Expand
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Highly Cited
2003
Highly Cited
2003
P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand
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