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Elacridar

National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of P-glycoprotein (Pgp) and breast… Expand
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Highly Cited
2012
Highly Cited
2012
Sunitinib is an orally active, multitargeted tyrosine kinase inhibitor which has been used for the treatment of metastatic renal… Expand
Highly Cited
2009
Highly Cited
2009
PurposeOveractivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: Imatinib, a BCR-ABL tyrosine kinase inhibitor, is a substrate of the efflux transporters P-glycoprotein (P-gp; ABCB1… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: Breast cancer resistance protein (ABCG2) substantially limits the oral bioavailability of topotecan. Coadministration… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of… Expand
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Highly Cited
2007
Highly Cited
2007
PurposePreviously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator… Expand
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Highly Cited
2006
Highly Cited
2006
Multidrug-resistant (MDR) cancer may be treated using combinations of encapsulated cytotoxic drugs and chemosensitizers. To… Expand
Highly Cited
2005
Highly Cited
2005
Imatinib mesylate (signal transduction inhibitor 571, Gleevec) is a potent and selective tyrosine kinase inhibitor, which was… Expand
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Highly Cited
2003
Highly Cited
2003
P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand
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