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PurposeTo study the inhibition patterns of the three major human ABC transporters P-gp (ABCB1), BCRP (ABCG2) and MRP2 (ABCC2… Expand Understanding mechanisms associated with flavonoid neuroprotection is complicated by the lack of information on their ability to… Expand The breast cancer resistance protein (BCRP/ABCG2) is, like P-glycoprotein (P-gp), a member of the ABC family of drug transporters… Expand Overexpression of the breast cancer resistance protein (BCRP/ABCG2) confers multidrug resistance (MDR) to tumor cells and often… Expand P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand PURPOSE
We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate-binding cassette… Expand Previously, we have reported that a multidrug-resistant, mitoxantrone (MX)-selected cell line, MCF7/MX, is highly cross-resistant… Expand BACKGROUND AND METHODS
Breast cancer resistance protein (BCRP/MXR/ABCP) is a multidrug-resistance protein that is a member of the… Expand Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected for resistance to topotecan… Expand N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]- phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide… Expand