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GF 120918
Known as:
GF-120918
, GF120918
, GG 918
National Institutes of Health
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1 relation
Broader (1)
Elacridar
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs
P. Matsson
,
Jenny M. Pedersen
,
U. Norinder
,
Christel A. S. Bergström
,
P. Artursson
Pharmaceutical Research
2009
Corpus ID: 11983869
PurposeTo study the inhibition patterns of the three major human ABC transporters P-gp (ABCB1), BCRP (ABCG2) and MRP2 (ABCC2…
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Highly Cited
2004
Highly Cited
2004
Flavonoid permeability across an in situ model of the blood-brain barrier.
K. Youdim
,
M. Qaiser
,
D. Begley
,
C. Rice-evans
,
N. Abbott
Free Radical Biology & Medicine
2004
Corpus ID: 6340968
Highly Cited
2004
Highly Cited
2004
Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.
S. Cisternino
,
C. Mercier
,
F. Bourasset
,
F. Roux
,
J. Scherrmann
Cancer Research
2004
Corpus ID: 7042764
The breast cancer resistance protein (BCRP/ABCG2) is, like P-glycoprotein (P-gp), a member of the ABC family of drug transporters…
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Highly Cited
2003
Highly Cited
2003
Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.
E. L. Volk
,
E. Schneider
Cancer Research
2003
Corpus ID: 12789969
The existence of an ATP-dependent methotrexate (MTX) efflux mechanism has long been postulated; however, until recently, the…
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Highly Cited
2002
Highly Cited
2002
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
C. M. Kruijtzer
,
J. Beijnen
,
+5 authors
J. Schellens
Journal of Clinical Oncology
2002
Corpus ID: 23413733
PURPOSE We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate-binding cassette…
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Highly Cited
2002
Highly Cited
2002
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.
E. L. Volk
,
Kate M Farley
,
Yan Wu
,
Fei Li
,
R. Robey
,
E. Schneider
Cancer Research
2002
Corpus ID: 14003673
Previously, we have reported that a multidrug-resistant, mitoxantrone (MX)-selected cell line, MCF7/MX, is highly cross-resistant…
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Highly Cited
2000
Highly Cited
2000
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
J. Jonker
,
J. Smit
,
+4 authors
A. Schinkel
Journal of the National Cancer Institute
2000
Corpus ID: 13241523
BACKGROUND AND METHODS Breast cancer resistance protein (BCRP/MXR/ABCP) is a multidrug-resistance protein that is a member of the…
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Highly Cited
1999
Highly Cited
1999
The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.
J. Allen
,
R. F. Brinkhuis
,
J. Wijnholds
,
A. Schinkel
Cancer Research
1999
Corpus ID: 12411655
Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected for resistance to topotecan…
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Highly Cited
1999
Highly Cited
1999
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.
M. D. Bruin
,
K. Miyake
,
T. Litman
,
R. Robey
,
S. Bates
Cancer Letters
1999
Corpus ID: 33563416
Highly Cited
1993
Highly Cited
1993
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.
Fran
,
ois Hyafil
,
C. Vergely
,
Pierre Du Vignaud
,
T. Grand‐Perret
Cancer Research
1993
Corpus ID: 17855057
N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]- phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide…
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