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GF 120918

Known as: GF-120918, GF120918, GG 918 
National Institutes of Health

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Elacridar

Papers overview

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Highly Cited
2011
Highly Cited
2011
Evaluation of Limiting Brain Penetration Related to P-glycoprotein and Breast Cancer Resistance Protein Using [11C]GF120918 by PET in Mice
PurposeGF120918 has a high inhibitory effect on P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). We developed… 
Highly Cited
2006
Highly Cited
2006
EXPRESSION AND FUNCTIONAL ACTIVITY OF BREAST CANCER RESISTANCE PROTEIN (BCRP, ABCG2) TRANSPORTER IN THE HUMAN CHORIOCARCINOMA CELL LINE BEWO
1 Breast cancer resistance protein (BCRP, ABCG2) is a drug efflux transporter that is believed to affect the drug disposition of… 
Highly Cited
2006
Highly Cited
2006
Differential Involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in Biliary Excretion of 4-Methylumbelliferyl Glucuronide and Sulfate in the Rat
The hepatic excretion of hydrophilic conjugates, end products of phase II metabolism, is not completely understood. In the… 
Highly Cited
2006
Highly Cited
2006
IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
The effects of hepatic uptake and efflux transporters on erythromycin (ERY) disposition and metabolism were examined by comparing… 
2006
2006
Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier.
The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor… 
Highly Cited
2005
Highly Cited
2005
Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein
Breast cancer resistance protein (Bcrp/Abcg2) is a new efflux transporter found at the blood-brain barrier (BBB) of humans and… 
Highly Cited
2003
Highly Cited
2003
Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir
Using a mouse model, we tested the effects of in vivo P-glycoprotein inhibition to enhance the oral uptake and penetration into… 
Highly Cited
2003
Highly Cited
2003
Midazolam Exhibits Characteristics of a Highly Permeable P-Glycoprotein Substrate
AbstractPurpose. The purpose of this study was to investigate whether midazolam exhibits characteristics of a highly permeable P… 
Highly Cited
2001
Highly Cited
2001
Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines.
Highly Cited
2001
Highly Cited
2001
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients
Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux… 
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