GG918
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
AbstractPurpose. To determine whether female sex-steroid hormones and their metabolites can modulate P-glycoprotein (P-gp…
P-Glycoprotein (P-gp) has been hypothesized to modulate intestinal drug metabolism by increasing the exposure of drug to…
The disposition of tacrolimus and the influence of cyclosporine, troleandomycin, and GF120918 (GG918, or N-[4-[2-(1,2,3,4…
As discussed in earlier articles, predictions of in vivo drug-drug interactions from in vitro studies is a subject of high…
AbstractPurpose. To investigate in vitro if P-glycoprotein (P-gp) transport can differentiate between antibiotic drugs exhibiting…
Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux…
The human multidrug transporter MDR1 P-glycoprotein and the multidrug resistance proteins MRP1 and MRP2 transport a range of…
SummaryThe acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl}-9,10…
We sought to develop an assay for measuring the inhibition of P-glycoprotein (Pgp) function in whole blood as an indicator of in…