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GG918

National Institutes of Health

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Elacridar

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Highly Cited
2006
Highly Cited
2006
IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
The effects of hepatic uptake and efflux transporters on erythromycin (ERY) disposition and metabolism were examined by comparing… 
2006
2006
Stromal cells extracted from ovarian cancer express functional multi drugs resistance proteins: ATP bindig casset and Major vault protein.
2072 Background: Stromal cells play a central role for the growth of tumor cells. The functional contribution of these cells in… 
Highly Cited
2004
Highly Cited
2004
Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus…
The effects of hepatic uptake and efflux transporters on metabolism of digoxin were examined in isolated rat hepatocytes versus… 
Highly Cited
2003
Highly Cited
2003
Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
The disposition of tacrolimus and the influence of cyclosporine, troleandomycin, and GF120918 (GG918, or N-[4-[2-(1,2,3,4… 
2002
2002
Effect of hr‐IL2 treatment on intestinal P‐glycoprotein expression and activity in Caco‐2 cells
Caco‐2 cells were used to investigate the effect of human recombinant interleukin‐2 (IL2) on intestinal P‐glycoprotein (P‐gp… 
Highly Cited
2001
Highly Cited
2001
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients
Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux… 
2000
2000
Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line
Abstract. The potential clinical use of technetium-99m labeled sestamibi (Tc-MIBI) and tetrofosmin (Tc-Tfos) to image tumours is… 
2000
2000
In vitro comparison of sestamibi, tetrofosmin, and furifosmin as agents for functional imaging of multidrug resistance in tumors.
Sestamibi, tetrofosmin, and furifosmin are 99mTc-labeled myocardial perfusion imaging agents which have been shown to be… 
1999
1999
Membranoproliferative glomerulonephritis following gemcitabine and vinorelbine chemotherapy for peritoneal mesothelioma.
The most common types of malignancy-associated glomerular disease are membranous glomerulonephritis, minimal change… 
1997
1997
Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells
The drug GG918 has been specifically developed for overcoming MDR phenotype and is now in use in clinical trials. In this study… 
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