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EIF4E wt Allele

Known as: EIF4E1, Eukaryotic Translation Initiation Factor 4E wt Allele, EIF4EL1 
Human EIF4E wild-type allele is located within 4q21-q25 and is approximately 59 kb in length. This allele, which encodes eukaryotic translation… 
National Institutes of Health

Related topics

Related topics

12 relations
Cytokine Signaling ProcessEukaryotic Initiation Factor-4FGenetic Translation ProcessInsulin/Insulin Receptor Signaling Pathway

Broader (1)

EIF4E gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Casein kinase 1ε promotes cell proliferation by regulating mRNA translation.
Deregulation of translation initiation factors contributes to many pathogenic conditions, including cancer. Here, we report the… 
2008
2008
Activation of p53 stimulates proteasome‐dependent truncation of eIF4E‐binding protein 1 (4E‐BP1)
Background information. The translational inhibitor protein 4E‐BP1 [eIF4E (eukaryotic initiation factor 4E)‐binding protein 1… 
2006
2006
IGF-I stimulates protein synthesis in skeletal muscle through multiple signaling pathways during sepsis.
Chronic septic abscess formation causes an inhibition of protein synthesis in gastrocnemius not observed in rats with a sterile… 
Highly Cited
2005
Highly Cited
2005
Inhibition of Host and Viral Translation during Vesicular Stomatitis Virus Infection
In cells that allow replication of vesicular stomatitis virus (VSV), there are two phases of translation inhibition: an early… 
2002
2002
Positive and Negative Effects of the Major Mammalian Messenger Ribonucleoprotein p50 on Binding of 40 S Ribosomal Subunits to the Initiation Codon of β-Globin mRNA*
p50, the major core protein bound to mammalian mRNAs, has been reported to stimulate translation at low p50/mRNA ratios and… 
Highly Cited
2001
Highly Cited
2001
Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain.
The striking correlation between neuronal vulnerability and down-regulation of translation suggests that this cellular process… 
Review
2001
Review
2001
Interplay between insulin and nutrients in the regulation of translation factors.
Protein synthesis in mammalian cells is regulated through alterations in the states of phosphorylation of eukaryotic initiation… 
2000
2000
Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells.
In PC12 phaeochromocytoma cells, protein synthesis is activated by epidermal and nerve growth factors (EGF and NGF). EGF and NGF… 
2000
2000
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
Ischaemia was obtained in vitro by subjecting nerve-growth-factor-differentiated PC12 cells to glucose deprivation plus anoxia… 
Highly Cited
1998
Highly Cited
1998
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111).
The effects of insulin and rapamycin on the phosphorylation of the translation regulator, initiation factor 4E-binding protein 1… 
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