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Insulin/Insulin Receptor Signaling Pathway

Known as: Insulin signaling pathway 
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase… 
National Institutes of Health

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ACACA wt AlleleAKT2 protein, humanARAF wt AlleleBRAF protein, human

Papers overview

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Highly Cited
2019
Highly Cited
2019
Identification of signaling cascade in the insulin signaling pathway in response to nanopolystyrene particles
Abstract The molecular response of animals to nanoplastic particles is still largely unclear. In this study, we employed a… 
Review
2017
Review
2017
A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus
MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA… 
Highly Cited
2015
Highly Cited
2015
Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity.
SCOPE Insulin resistance represents an independent risk factor for metabolic and cardiovascular diseases. Researchers have been… 
Highly Cited
2010
Highly Cited
2010
Gene up-regulation in response to predator kairomones in the water flea, Daphnia pulex
BackgroundNumerous cases of predator-induced polyphenisms, in which alternate phenotypes are produced in response to extrinsic… 
Highly Cited
2008
Highly Cited
2008
Dissection of the insulin signaling pathway via quantitative phosphoproteomics
The insulin signaling pathway is of pivotal importance in metabolic diseases, such as diabetes, and in cellular processes, such… 
Highly Cited
2007
Highly Cited
2007
Akt Mediates the Effect of Insulin on Epithelial Sodium Channels by Inhibiting Nedd4-2*
The epithelial sodium channel (ENaC) plays an important role in transepithelial Na+ absorption; hence its function is essential… 
Highly Cited
2007
Highly Cited
2007
Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet.
Green tea has antidiabetic, antiobesity, and anti-inflammatory activities in animal models, but the molecular mechanisms of these… 
Highly Cited
2005
Highly Cited
2005
Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress.
All cells adapt to hypertonic stress by regulating their volume after shrinkage, by accumulating organic osmolytes, and by… 
Highly Cited
2004
Highly Cited
2004
Angiotensin II Impairs the Insulin Signaling Pathway Promoting Production of Nitric Oxide by Inducing Phosphorylation of Insulin Receptor Substrate-1 on Ser312 and Ser616 in Human Umbilical Vein…
It has been suggested that serine (Ser) phosphorylation of insulin receptor substrate-1 (IRS-1) decreases the ability of IRS-1 to… 
Highly Cited
2002
Highly Cited
2002
A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling*
Recruitment of intracellular glucose transporter 4 (GLUT4) to the plasma membrane of fat and muscle cells in response to insulin… 
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