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Insulin/Insulin Receptor Signaling Pathway

Known as: Insulin signaling pathway 
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase… 
National Institutes of Health

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50 relations
ACACA wt AlleleAKT2 protein, humanARAF wt AlleleBRAF protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A new oxovanadium complex enhances renal function by improving insulin signaling pathway in diabetic mice.
2012
2012
Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma*
Background: ERK phosphorylation is enhanced by heparanase, an enzyme associated with aggressive behavior of multiple myeloma… 
2009
2009
Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.
BACKGROUND In metabolic syndrome, down-regulation of the insulin signaling leads to insulin-regulated metabolism and… 
2007
2007
A Lupinoside prevented fatty acid induced inhibition of insulin sensitivity in 3T3 L1 adipocytes
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes mellitus, an insidious… 
Review
2005
Review
2005
Obesity, breast cancer and the role of adipocytokines.
Obesity is a worldwide problem which impacts the risk and prognosis of some of the more common forms of cancer, including breast… 
Highly Cited
2002
Highly Cited
2002
A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling*
Recruitment of intracellular glucose transporter 4 (GLUT4) to the plasma membrane of fat and muscle cells in response to insulin… 
Highly Cited
1996
Highly Cited
1996
Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.
Interaction of the activated insulin receptor (IR) with its substrate, insulin receptor substrate 1 (IRS-1), via the… 
1995
1995
Involvement of Janus kinases in the insulin signaling pathway.
The adaptor molecule growth-factor-receptor-bound protein-2 (Grb2) plays a role in insulin action since it links tyrosine… 
1995
1995
Insulin-dependent Tyrosine Phosphorylation of the vav Proto-oncogene Product in Cells of Hematopoietic Origin (*)
Insulin activates the ras signaling pathway and promotes hematopoietic cell proliferation. One possible mediator in such… 
1989
1989
Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.
Previous studies [Summercorn et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 8834-8838; Klarlung & Czech (1988) J. Biol. Chem… 
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