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EIF4E gene

Known as: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EIF4E-LIKE 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E FAMILY, MEMBER 1 
This gene is involved in translation initiation.
National Institutes of Health

Related topics

Related topics

9 relations
Cytokine Signaling ProcessEukaryotic Initiation Factor-4EEukaryotic Translation Initiation Factor 4E, humanGenetic Translation Process

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EIF4E wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
The progression of cancers from primary tumors to invasive and metastatic stages accounts for the overwhelming majority of cancer… 
Highly Cited
2014
Highly Cited
2014
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation… 
Highly Cited
2012
Highly Cited
2012
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.
The eukaryotic initiation factor 4E (eIF4E) plays a central role in the initiation of gene translation and subsequent protein… 
Highly Cited
2007
Highly Cited
2007
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
Background Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E… 
Highly Cited
2006
Highly Cited
2006
Regulation of Eukaryotic Initiation Factor 4E by Converging Signaling Pathways during Metabotropic Glutamate Receptor-Dependent Long-Term Depression
Long-term depression (LTD) is an activity-dependent decrease in synaptic efficacy that can be induced in hippocampal area CA1 by… 
Highly Cited
2005
Highly Cited
2005
The recessive potyvirus resistance gene pot-1 is the tomato orthologue of the pepper pvr2-eIF4E gene
The translation initiation factor 4E (eIF4E) has been implicated in naturally occurring resistance to Potato virus Y (PVY… 
Highly Cited
2005
Highly Cited
2005
eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR
The eukaryotic translation initiation factor eIF4E is a critical modulator of cellular growth with functions in the nucleus and… 
Highly Cited
2004
Highly Cited
2004
Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.
Although the activity of the translation initiation factor eIF4F is regulated in part by translational repressors (4E-BPs) that… 
Highly Cited
2002
Highly Cited
2002
Loss-of-Susceptibility Mutants of Arabidopsis thaliana Reveal an Essential Role for eIF(iso)4E during Potyvirus Infection
Review
1997
Review
1997
Molecular mechanisms for the control of translation by insulin.
Insulin acutely stimulates protein synthesis in mammalian cells, and this involves activation of the process of mRNA translation… 
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