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A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity
TLDR
The receptor-like cytoplasmic kinase BIK1 is identified that is rapidly phosphorylated upon flagellin perception, depending on both FLS2 and BAK1, and is an essential component in MAMP signal transduction, which links the MAMP receptor complex to downstream intracellular signaling.
Differential innate immune signalling via Ca2+ sensor protein kinases
TLDR
Ca2+ signalling complexity is revealed and key positive roles of specific CDPKs are demonstrated in initial MAMP signalling in plant innate immune signalling.
Direct Ubiquitination of Pattern Recognition Receptor FLS2 Attenuates Plant Innate Immunity
TLDR
This study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases for attenuation of immune signaling.
Plant Pattern Recognition Receptors
TLDR
This chapter describes the purification of complex PGN from sources such as gram-positive bacteria, from which PGN isolation is facilitated due to its larger content in their cell wall, and includes the production of recombinant LysM proteins to analyze their PGN interaction.
BACE1 regulates voltage-gated sodium channels and neuronal activity
TLDR
BACE1 inhibitors may normalize membrane excitability in Alzheimer's disease patients with elevated BACE1 activity and regulate Nav1 α-subunit levels and controls cell-surface sodium current densities.
Bifurcation of Arabidopsis NLR Immune Signaling via Ca2+-Dependent Protein Kinases
TLDR
Functional genomic and biochemical genetic screens identified six closely related Arabidopsis Ca2+-dependent protein kinases (CPKs) in mediating bifurcate immune responses activated by NLR proteins, RPS2 and RPM1, and delineate b ifurcation of complex signaling mechanisms downstream of NLR immune sensors mediated by the myriad action of CPKs with distinct substrate specificity and subcellular dynamics.
RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB
TLDR
The results demonstrate that RAR1 molecularly links PTI, effector virulence, and ETI, and supports that both pathogen virulence and plant disease resistance have evolved around PTI.
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