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Eukaryotic Translation Initiation Factor 4E, human

Known as: eIF4E, eIF-4F 25 kDa Subunit, eIF-4E 
Eukaryotic translation initiation factor 4E (217 aa, ~25 kDa) is encoded by the human EIF4E gene. This protein is involved in the initiation of mRNA… 
National Institutes of Health

Related topics

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13 relations
Cytokine Signaling ProcessEIF4E geneEukaryotic Initiation Factor-4FGenetic Translation Process

Papers overview

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2016
2016
Dual mTORC 1 / 2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer
There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its… 
2014
2014
RPL 24 : a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth
Partial loss of large ribosomal subunit protein 24 (RPL24) function is known to protect mice against Akt or Myc-driven cancers… 
2012
2012
mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
The mammalian/mechanistic target of rapamycin (mTOR) is a multifunctional serine/threonine kinase that is hyperactivated in… 
2011
2011
Analysis of eIF 4 E and 4 EBP 1 mRNAs in Head and Neck Cancer
Objectives/Hypothesis: The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1… 
2006
2006
Pifithrin- (cid:1) Enhances Chemosensitivity by a p38 Mitogen-Activated Protein Kinase-Dependent Modulation of the Eukaryotic Initiation Factor 4E in Malignant Cholangiocytes
Pifithrin- (cid:1) is the lead compound for a novel group of small molecules that are being developed for use as anticancer… 
2005
2005
The eukaryotic initiation factor 4E-binding proteins and apoptosis
Eukaryotic initiation factor 4E (eIF4E) is a key component of the translational machinery that is required for cap-dependent… 
2005
2005
4 EBP 1 phosphorylation is mediated by the FRAP-p 70 s 6 k pathway and is independent of mitogen-activated protein kinase ( insulin / signal transduction / translational control )
It has previously been argued that the repressor of protein synthesis initiation factor 4E, 4E-BP1, is a direct in vivo target of… 
2003
2003
Transforming Growth Factor-Attenuates N-Methyl-D-aspartic Acid Toxicity in Cortical Cultures by Preventing Protein Synthesis Inhibition through an Erk 1 / 2-dependent Mechanism *
Transforming growth factor(TGF), a ligand of the epidermal growth factor receptor, reduces the infarct size after focal cerebral… 
2001
2001
Transformation of Cloned Rat Embryo Fibroblasts Results in Increased Rates of Protein Synthesis and Phosphorylation of Eukaryotic Initiation Factor 4 E *
Eukaryotic initiation factor 4E (eIF-4E) is a 25-kDa phosphoprotein that binds to the 7-methylguanosine cap of mRNA and acts… 
1999
1999
Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E.
The present study examined potential mechanisms for the inhibition of protein synthesis in skeletal muscle after chronic alcohol… 
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