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Eukaryotic Translation Initiation Factor 4E, human

Known as: eIF4E, eIF-4F 25 kDa Subunit, eIF-4E 
Eukaryotic translation initiation factor 4E (217 aa, ~25 kDa) is encoded by the human EIF4E gene. This protein is involved in the initiation of mRNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Alternative splicing modulates the expression of many oncogene and tumor-suppressor isoforms. We have tested whether some… Expand
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Review
2005
Review
2005
Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends. Translation of mRNAs requires the binding… Expand
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Highly Cited
2005
Highly Cited
2005
The mammalian target of rapamycin (mTOR) has emerged as an important cancer therapeutic target. Rapamycin and its derivatives… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to regulate cell growth (increased cell… Expand
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Highly Cited
2004
Highly Cited
2004
Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulators invariably accompany… Expand
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Highly Cited
2002
Highly Cited
2002
The coordinated action of cell cycle progression and cell growth (an increase in cell size and cell mass) is critical for… Expand
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Highly Cited
2001
Highly Cited
2001
In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5' end of an mRNA. The… Expand
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Highly Cited
1999
Highly Cited
1999
The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The… Expand
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Highly Cited
1998
Highly Cited
1998
The present study identifies the operation of a signal tranduction pathway in mammalian cells that provides a checkpoint control… Expand
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Highly Cited
1995
Highly Cited
1995
Eukaryotic translation initiation factor 4E (eIF-4E), which possesses cap-binding activity, functions in the recruitment of mRNA… Expand
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