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EIF2AK1 gene

Known as: EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1, heme regulated initiation factor 2 alpha kinase, EIF2AK1 
This gene plays a role in the negative regulation of protein synthesis.
National Institutes of Health

Related topics

Related topics

11 relations
EIF2AK2 geneEIF2AK3 geneEukaryotic Translation Initiation Factor 2-Alpha Kinase 1PRKR gene

Narrower (1)

EIF2AK2 wt Allele

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition.
Heme-regulated eIF2alpha kinase [heme-regulated inhibitor (HRI)] plays a critical role in the regulation of protein synthesis by… 
Highly Cited
2002
Highly Cited
2002
Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.
The maturation and activation of newly synthesized molecules of the heme-regulated inhibitor of protein synthesis (HRI) in… 
Highly Cited
1999
Highly Cited
1999
Dual Role for Hsc70 in the Biogenesis and Regulation of the Heme-Regulated Kinase of the α Subunit of Eukaryotic Translation Initiation Factor 2
ABSTRACT The heme-regulated kinase of the α subunit of eukaryotic initiation factor 2 (HRI) is activated in rabbit reticulocyte… 
Review
1996
Review
1996
Postdischarge utilization of medical services by high-risk infants: experience in a large managed care organization.
BACKGROUND Infants discharged from intensive care nurseries are a high-risk infant (HRI) population known to have increased… 
Highly Cited
1993
Highly Cited
1993
Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase.
The heme-regulated inhibitor (HRI) of protein synthesis becomes activated in rabbit reticulocyte lysates in response to a variety… 
1991
1991
Tissue distribution and immunoreactivity of heme-regulated eIF-2 alpha kinase determined by monoclonal antibodies.
A highly purified preparation of heme-regulated inhibitor (HRI), an eIF-2 alpha kinase, from rabbit reticulocyte lysates has been… 
1989
1989
Disulfide bond formation in the regulation of eIF-2 alpha kinase by heme.
The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor (eIF)-2 alpha kinase (HRI) by hemin… 
Highly Cited
1987
Highly Cited
1987
Nucleotide sequence analysis of RepFIC, a basic replicon present in IncFI plasmids P307 and F, and its relation to the RepA replicon of IncFII plasmids
RepFIC is a basic replicon of IncFI plasmid P307 which is located within a 3.09-kilobase SmaI fragment. The nucleotide sequence… 
Highly Cited
1986
Highly Cited
1986
Restriction maps and homologies of the three plasmids of Agrobacterium rhizogenes strain A4.
Highly Cited
1979
Highly Cited
1979
Regulation of protein synthesis in rabbit reticulocyte lysates: additional initiation factor required for formation of ternary complex (eIF-2.GTP.Met-tRNAf) and demonstration of inhibitory effect of…
Heme deficiency in rabbit reticulocytes and their lysates leads to the activation of a heme-regulated translational inhibitor… 
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