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Regional manifestations and control of the immune system
- S. Saadi, L. Wrenshall, Jeffey L Platt
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 June 2002
Although immune responses are generally considered to be systemic, local events such as interaction of complement products with blood vessels and with inflammatory cells play a pivotal role in… Expand
Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.
- M. Bustos, T. Coffman, S. Saadi, J. Platt
- The Journal of clinical investigation
- 1 September 1997
Lipid inflammatory mediators are thought to play a critical role in the pathogenesis of vascular injury. Among the events which might cause the synthesis of eicosanoids in blood vessels is activation… Expand
Nucleotide sequence analysis of RepFIC, a basic replicon present in IncFI plasmids P307 and F, and its relation to the RepA replicon of IncFII plasmids.
RepFIC is a basic replicon of IncFI plasmid P307 which is located within a 3.09-kilobase SmaI fragment. The nucleotide sequence of this region has been determined and shown to be homologous with the… Expand
Structural, molecular, and genetic analysis of the kilA operon of broad-host-range plasmid RK2.
- P. Goncharoff, S. Saadi, C. Chang, L. H. Saltman, D. Figurski
- Biology, Medicine
- Journal of bacteriology
- 1 June 1991
The kil loci (kilA, kilB, kilC, and kilE) of incompatibility group P (IncP), broad-host-range plasmid RK2 were originally detected by their potential lethality to Escherichia coli host cells.… Expand
Differential Regulation of Endothelial Cell Activation by Complement and Interleukin 1&agr;
Activation of complement on endothelium triggers physiological changes that promote coagulation, thrombosis, and inflammation. Unlike agonists such as cytokines and endotoxin that induce these… Expand
Induction of tissue factor mRNA in acute vascular rejection: localization by in situ reverse transcriptase polymerase chain reaction.
Endothelial cell activation by pore-forming structures: pivotal role for interleukin-1alpha.
BACKGROUND Interaction of complement with endothelial cells (ECs) underlies the development of inflammation and coagulation in disease. Assembly of the membrane attack complex (MAC) of complement on… Expand
Human natural killer cells induce morphologic changes in porcine endothelial cell monolayers.
In this study, we have investigated the early in vitro effects of natural killer (NK) cells on porcine aortic endothelial cell (PAEC) monolayers. Incubation of effector cells containing about 70%… Expand
Characterization of the basic replicons of the chimeric R/Ent plasmid pCG86 and the related Ent plasmid P307.
Restriction-enzyme fragments that can replicate autonomously after circularization were isolated from the chimeric R/Ent plasmid pCG86 and the Ent plasmid P307. Two such regions containing a basic… Expand
PLATELET-MEDIATED ACTIVATION OF ENDOTHELIAL CELLS: IMPLICATIONS FOR THE PATHOGENESIS OF TRANSPLANT REJECTION1
Background. Platelets exert their normal functions at sites of endothelial disruption by plugging discontinuities in blood vessels and secreting products that promote thrombosis, inflammation, and… Expand