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PRKR gene

Known as: EIF2AK2, EIF2AK2 Gene, Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Gene 
This gene plays a role in the negative regulation of protein synthesis.
National Institutes of Health

Related topics

Related topics

8 relations
EIF2AK1 geneEIF2AK2 protein, humanEIF2AK2 wt AllelePhosphorylation
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has… Expand
Highly Cited
2016
Highly Cited
2016
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
A primary insult to the pancreatic islets of Langerhans, leading to the activation of innate immunity, has been suggested as an… Expand
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Highly Cited
2015
Highly Cited
2015
Reduced protein synthesis in schizophrenia patient-derived olfactory cells
Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel insights into the cellular pathology of… Expand
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2013
2013
Utilizing protein structure to identify non-random somatic mutations
BackgroundHuman cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome… Expand
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2013
2013
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
A chemical screen designed to identify novel inducers of autophagy led to the discovery that signal transducer and activator of… Expand
Highly Cited
2012
Highly Cited
2012
Novel role of PKR in inflammasome activation and HMGB1 release
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high… Expand
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2011
2011
Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
IntroductionThe objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression… Expand
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Highly Cited
2009
Highly Cited
2009
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic… Expand
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Review
2008
Review
2008
Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades
  • C. Carter
  • Neurochemistry International
  • 2008
    • Corpus ID: 45595599
The products of the Herpes simplex (HSV-1) genome interact with many Alzheimer's disease susceptibility genes or proteins. These… Expand
Highly Cited
2008
Highly Cited
2008
Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines.
Outbreaks of dengue disease are constant threats to tropical and subtropical populations but range widely in severity, from mild… Expand
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