Skip to search formSkip to main contentSkip to account menu

PRKR gene

Known as: EIF2AK2, EIF2AK2 Gene, Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Gene 
This gene plays a role in the negative regulation of protein synthesis.
National Institutes of Health

Related topics

Related topics

8 relations
EIF2AK1 geneEIF2AK2 protein, humanEIF2AK2 wt AllelePhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identifying Key Genes and Functionally Enriched Pathways in Sjögren’s Syndrome by Weighted Gene Co-Expression Network Analysis
Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by dry mouth and eyes. To date, the exact molecular… 
Highly Cited
2018
Highly Cited
2018
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Highly Cited
2016
Highly Cited
2016
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has… 
Highly Cited
2016
Highly Cited
2016
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
A primary insult to the pancreatic islets of Langerhans, leading to the activation of innate immunity, has been suggested as an… 
Review
2015
Review
2015
The role of STAT3 in autophagy
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular… 
Highly Cited
2015
Highly Cited
2015
Reduced protein synthesis in schizophrenia patient-derived olfactory cells
Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel insights into the cellular pathology of… 
Highly Cited
2013
Highly Cited
2013
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
A chemical screen designed to identify novel inducers of autophagy led to the discovery that signal transducer and activator of… 
Highly Cited
2012
Highly Cited
2012
Novel role of PKR in inflammasome activation and HMGB1 release
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high… 
2011
2011
Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
IntroductionThe objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression… 
Highly Cited
2008
Highly Cited
2008
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)