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PRKR gene
Known as:
EIF2AK2
, EIF2AK2 Gene
, Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Gene
This gene plays a role in the negative regulation of protein synthesis.
National Institutes of Health
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Related topics
Related topics
8 relations
EIF2AK1 gene
EIF2AK2 protein, human
EIF2AK2 wt Allele
Phosphorylation
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identifying Key Genes and Functionally Enriched Pathways in Sjögren’s Syndrome by Weighted Gene Co-Expression Network Analysis
Qiuming Yao
,
Zhen-yu Song
,
Bin Wang
,
Q. Qin
,
Jin-an Zhang
Frontiers in Genetics
2019
Corpus ID: 207958793
Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by dry mouth and eyes. To date, the exact molecular…
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Highly Cited
2018
Highly Cited
2018
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Cindy Meyer
,
Aitor Garzia
,
M. Mazzola
,
S. Gerstberger
,
H. Molina
,
T. Tuschl
Molecules and Cells
2018
Corpus ID: 3432080
Highly Cited
2016
Highly Cited
2016
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
M. Xie
,
Yan Yu
,
+10 authors
D. Tang
Nature Communications
2016
Corpus ID: 233028
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has…
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Highly Cited
2016
Highly Cited
2016
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
M. Lundberg
,
L. Krogvold
,
Enida Kuric
,
K. Dahl-Jørgensen
,
O. Skog
Diabetes
2016
Corpus ID: 7145039
A primary insult to the pancreatic islets of Langerhans, leading to the activation of innate immunity, has been suggested as an…
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Review
2015
Review
2015
The role of STAT3 in autophagy
Liangkun You
,
Zhanggui Wang
,
+6 authors
W. Han
Autophagy
2015
Corpus ID: 13246032
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular…
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Highly Cited
2015
Highly Cited
2015
Reduced protein synthesis in schizophrenia patient-derived olfactory cells
J. English
,
Y. Fan
,
+8 authors
D. Cotter
Translational Psychiatry
2015
Corpus ID: 11514200
Human olfactory neurosphere-derived (ONS) cells have the potential to provide novel insights into the cellular pathology of…
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Highly Cited
2013
Highly Cited
2013
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
M. Niso-Santano
,
S. Shen
,
+8 authors
G. Kroemer
Autophagy
2013
Corpus ID: 32134942
A chemical screen designed to identify novel inducers of autophagy led to the discovery that signal transducer and activator of…
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Highly Cited
2012
Highly Cited
2012
Novel role of PKR in inflammasome activation and HMGB1 release
B. Lu
,
Takahisa Nakamura
,
+17 authors
K. Tracey
Nature
2012
Corpus ID: 4392461
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1β, IL-18 and high…
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2011
2011
Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
T. O’Hanlon
,
L. Rider
,
+8 authors
F. Miller
Arthritis Research & Therapy
2011
Corpus ID: 7215790
IntroductionThe objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression…
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Highly Cited
2008
Highly Cited
2008
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
S. Rothenburg
,
E. Seo
,
J. Gibbs
,
T. E. Dever
,
K. Dittmar
Nature Structural &Molecular Biology
2008
Corpus ID: 6039063
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic…
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