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Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1

Known as: Heme-Regulated Eukaryotic Initiation Factor eIF-2-Alpha Kinase, Heme-Controlled Repressor, HCR 
Eukaryotic translation initiation factor 2-alpha kinase 1 (630 aa, ~71 kDa) is encoded by the human EIF2AK1 gene. This protein plays a role in both… 
National Institutes of Health

Related topics

Related topics

15 relations
EIF2AK1 geneEIF2AK2 protein, humanEIF2AK2 wt AlleleEnzyme Gene

Broader (2)

Protein-Serine-Threonine KinaseseIF-2 Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
HRImyc F TAAGCTTGGTACCGAGCTCGgccgccaccATGGAACAAAAACTCATCTCAGAAGAGGATCTGCAGGGGGGCAACTCCGGGGTC HRImyc R CGCGGGCCCTCTAGACTCGATCACAATCCCACGCCCCCATCCTTTC PKR gBlock…
2013
2013
Vimentin is a component of a complex that binds to the 5′‐UTR of human heme‐regulated eIF2α kinase mRNA and regulates its translation
2007
2007
Eukaryotic initiation factor 2α kinase is a nitric oxide‐responsive mercury sensor enzyme: Potent inhibition of catalysis by the mercury cation and reversal by nitric oxide
2006
2006
Sensory Denervation Modulates eIF-2 Alpha Kinase Expression in the Rabbit Lacrimal Gland
Purpose: To investigate the hypothesis that sensory denervation of the rabbit lacrimal gland results in dysregulation of protein… 
2002
2002
Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2alpha kinase.
We have used human cell lines, namely, K562 and HeLa cells as model systems in understanding the mechanism of lead toxicity and… 
1998
1998
Expression and purification of the alpha-subunit of eukaryotic initiation factor eIF2: use as a kinase substrate.
The alpha-subunit of eukaryotic initiation factor eIF2 (eIF2alpha) plays an important role in the regulation of mRNA translation… 
1996
1996
Association of HSP90 with the heme-regulated eukaryotic initiation factor 2α kinase—A collaboration for regulating protein synthesis
Among the various heat shock proteins (HSPs), members of the HSP70 and HSP90 families have drawn particular attention due to… 
Review
1994
Review
1994
eIF-2 kinases: regulators of general and gene-specific translation initiation.
1992
1992
Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes.
Phosphorylation of the alpha-subunit (38 kDa) of eukaryotic initiation factor 2 (eIF-2 alpha) regulates initiation of protein… 
1986
1986
Structural studies on the eukaryotic chain initiation factor 2 from rabbit reticulocytes and brine shrimp Artemia embryos. Phosphorylation by the heme-controlled repressor and casein kinase II.
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