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Dicumarol

Known as: Bis(4-hydroxycoumarin-3-yl)methane, 2H-1-Benzopyran-2-one, 3,3'-methylenebis(4-hydroxy)-, bis-hydroxycoumarin 
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
National Institutes of Health

Related topics

Related topics

44 relations
Alcoholic Intoxication, ChronicAneurysmAscorbic Acid DeficiencyBacterial Endocarditis

Broader (3)

AnticoagulantsEnzyme InhibitorsUncoupling Agents

Narrower (2)

Dicoumarinazodicoumarol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2002
Review
2002
Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.
Although it is generally accepted that free radicals are involved in the neurodegenerative process occurring in the dopaminergic… 
Highly Cited
1988
Highly Cited
1988
Distribution of dt diaphorase in the rat brain: Biochemical and immunohistochemical studies
Highly Cited
1978
Highly Cited
1978
Metabolism of benzo(a)pyrene-3,6-quinone and 3-hydroxybenzo(a)pyrene in liver microsomes from 3-methylcholanthrene-treated rats. A possible role of DT-diaphorase in the formation of glucuronyl…
Highly Cited
1975
Highly Cited
1975
Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.
Highly Cited
1973
Highly Cited
1973
Binding of Ca 2+ to normal and dicoumarol-induced prothrombin.
Highly Cited
1970
Highly Cited
1970
Impairment of drug metabolism in man by allopurinol and nortriptyline.
Abstract Normal medical students received either allopurinol or nortriptyline. To quantitate changes in rates of drug metabolism… 
Highly Cited
1970
Highly Cited
1970
Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide.
Highly Cited
1967
Highly Cited
1967
Energy-linked reactions in photosynthetic bacteria. I. Succinatelinked ATP-driven NAD reduction by Rhodospirillum rubrum chromatophores.
Highly Cited
1965
Highly Cited
1965
PETECHIAE, ECCHYMOSES, AND NECROSIS OF SKIN INDUCED BY COUMARIN CONGENERS: RARE, OCCASIONALLY LETHAL COMPLICATION OF ANTICOAGULANT THERAPY.
A rare complication of coumarin-congener anticoagulant therapy characterized by a sequence of skin lesions (petechiae, ecchymoses… 
Highly Cited
1955
Highly Cited
1955
Effects of restriction of dietary fat and cholesterol upon serum lipids and lipoproteins in patients with hypertension.
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