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Dealkylation
Known as:
Dealkylations
The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
National Institutes of Health
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Related topics
Related topics
3 relations
Alkylation
aspects of radiation effects
physiological aspects
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Pharmacokinetic interaction between neuroleptics and tricyclic antidepressants in the rat.
L. Gram
,
J. Christiansen
,
K. Overø
Acta Pharmacologica et Toxicologica
2009
Corpus ID: 28325131
The metabolism and disposition of 14C-nortriptyline and 14C-imipramine in the rat was studied after intraperitoneal…
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2005
2005
Oxene donors yield low-level chemiluminescence with microsomes and isolated cytochrome P-450.
E. Cadenas
,
H. Sies
,
H. Graf
,
V. Ullrich
European Journal of Biochemistry
2005
Corpus ID: 40244149
1 Microsomes supplemented with different oxene donors yield light emission. The ability of oxene donors to support…
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1997
1997
Stereoselective metabolism of famprofazone in humans: N-dealkylation and beta- and p-hydroxylation.
Ho-Sang Shin
Chirality
1997
Corpus ID: 13238383
Following administration of famprofazone to humans, the stereoselective metabolism from the drug to its known metabolites…
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1982
1982
Heterogeneous distribution of the cytochrome P-450 monooxygenase system in rat liver lobes.
T. Matsubara
,
A. Touchi
,
A. Ogawa
Japanese Journal of Pharmacology
1982
Corpus ID: 26502236
Enzyme distribution in rat liver lobes was investigated using liver homogenate as the enzyme source. When the content or the…
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1982
1982
Biotransformation of coumarin derivatives (1). 7-alkoxycoumarin O-dealkylase in liver microsomes.
T. Matsubara
,
E. Yoshihara
,
T. Iwata
,
Y. Tochino
,
Y. Hachino
Japanese Journal of Pharmacology
1982
Corpus ID: 5985698
The in vitro metabolic fate of 7-alkoxycoumarin was studied using liver microsomes. Microsomal enzyme catalyzed dealkylation of 7…
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1979
1979
Mechanism of the dealkylation of tertiary amines by hepatic oxygenases. Stable isotope studies with 1-benzyl-4-cyano-4-phenylpiperidine.
R. Mcmahon
,
H. W. Culp
,
J. Craig
,
N. Ekwuribe
Journal of Medicinal Chemistry
1979
Corpus ID: 42112843
The microsomal oxidative dealkylation of 1-benzyl-4-cyano-4-phenylpiperidine has been studied and the source of oxygen shown to…
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1975
1975
Enzymatic S-De-Ethylation and the Mechanism of S-Dealkylation 1
T. Farber
Proceedings of the Society for Experimental…
1975
Corpus ID: 45240277
Summary An NADPH- and oxygen-dependent enzymatic system responsible for the formation of acetaldehyde from ethyl-thioethers is…
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1971
1971
Metabolites of naloxone in human urine.
S. Weinstein
,
M. Pfeffer
,
J. Schor
,
L. Indindoli
,
M. Mintz
Journal of Pharmacy and Science
1971
Corpus ID: 38866764
Naloxone, 7,8-dihydro-14-hydroxynormorphinone, and N-allyl-7,8-dihydro-14-hydroxynormorphine have been idenfied in a human urine…
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Highly Cited
1966
Highly Cited
1966
Dealkylation studies on inhibited acetylcholinesterase.
D. Coult
,
D. Marsh
,
G. Read
Biochemical Journal
1966
Corpus ID: 5244861
1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation…
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1956
1956
Studies on the N-dealkylation of nitrogen mustard and triethylenemelamine by liver homogenates.
Nadkarni Mv
,
Trams Eg
Cancer Research
1956
Corpus ID: 209136655
Summary 1.A study has been made of the in vitro demethylation of nitrogen mustard and the deethylation of nitrogen mustard and…
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