Dealkylation

Known as: Dealkylations 
The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
National Institutes of Health

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2008
2008
Human butyrylcholinesterase (hBChE) hydrolyzes or scavenges a wide range of toxic esters, including heroin, cocaine, carbamate… (More)
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Review
2004
Review
2004
MDMA (3,4-methylenedioxymethamphetamine, ecstasy) is a widely misused psychostimulant drug abused among large segments of the… (More)
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Highly Cited
1998
Highly Cited
1998
Buprenorphine (BN) is a thebaine derivative with analgesic properties. To identify and characterize the cytochrome P450 (CYP… (More)
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Highly Cited
1997
Highly Cited
1997
Buprenorphine is a long acting analgesic of the opiate family. Recently, it has been proposed for the opioid dependency treatment… (More)
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Highly Cited
1997
Highly Cited
1997
The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic elimination occurs primarily by hepatic… (More)
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1996
1996
Alfentanil, sufentanil, and fentanyl are synthetic opioids that are metabolized by oxidative N-dealkylation in the liver. We have… (More)
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Review
1995
Review
1995
Cytochrome P450 isozyme 3A4 (CYP3A4) is a major isozyme in the human liver and is known to metabolize a larger variety of… (More)
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1993
1993
We undertook this study to answer several questions regarding nitrosamine metabolism. Kinetics of nitrosamine metabolism showed… (More)
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Highly Cited
1985
Highly Cited
1985
The O-dealkylation of pentoxyresorufin (7-pentoxyphenoxazone) by rat liver microsomes was examined. The reaction appeared highly… (More)
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Highly Cited
1985
Highly Cited
1985
The individual members of a homologous series of phenoxazone ethers related to ethoxyresorufin were O-dealkylated, and the parent… (More)
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