Skip to search formSkip to main contentSkip to account menu

Dantrolene Sodium

Known as: Dantrolene Sodium [Chemical/Ingredient], Sodium, Dantrolene 
The sodium salt form of dantrolene, a hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction… 
National Institutes of Health

Related topics

Related topics

14 relations
Calcium Channel Antagonists [MoA]Cerebral InfarctionCerebral PalsyDantrolene

Narrower (1)

Dantrium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Malignant hyperthermia: a review
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent… 
Highly Cited
2001
Highly Cited
2001
In vitro antioxidant properties of dantrolene sodium.
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. The… 
Highly Cited
1993
Highly Cited
1993
Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin
Mechanical stimulation of a single cell in a primary mixed glial cell culture induced a wave of increased intracellular calcium… 
Highly Cited
1991
Highly Cited
1991
Ineffectiveness of dantrolene sodium in the treatment of heatstroke
Study ObjectiveTo determine the efficacy of dantrolene sodium in the treatment of heatstroke. DesignRandomized, double-blind… 
Highly Cited
1989
Highly Cited
1989
Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons.
1. The function and ionic mechanism of a slow outward current were studied in large layer V neurons of cat sensorimotor cortex… 
Review
1986
Review
1986
Dantrolene
SummarySynopsis: Dantrolene sodium1 acts primarily by affecting calcium flux across the sarcoplasmic reticulum of skeletal muscle… 
Highly Cited
1977
Highly Cited
1977
The mechanism of action of dantrolene sodium.
Dantrolene sodium is thought to affect some step in the excitation-contraction coupling process. Using a point voltage clamp to… 
Highly Cited
1977
Highly Cited
1977
Dantrolene-associated hepatic injury. Incidence and character.
Highly Cited
1975
Highly Cited
1975
Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium.
Experiments are described which demonstrate that dantrolene sodium effectively terminates the syndrome of malignant hyperpyrexia… 
Highly Cited
1974
Highly Cited
1974
Effect of dantrolene sodium on calcium movements in single muscle fibres
DANTROLENE sodium or 1–[5–(p-nitrophenyl) furfurylidene amino] hydantoin sodium hydrate (DaNa) is a long-acting drug with… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)