Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium.

@article{Harrison1975ControlOT,
  title={Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium.},
  author={G. G. Harrison},
  journal={British journal of anaesthesia},
  year={1975},
  volume={47 1},
  pages={
          62-5
        }
}
  • G. Harrison
  • Published 1975
  • Medicine
  • British journal of anaesthesia
Experiments are described which demonstrate that dantrolene sodium effectively terminates the syndrome of malignant hyperpyrexia induced in susceptible swine by exposure to halothane. Dantrolene is also shown to block initiation of the syndrome of malignant hyperpyrexia by halothane in MHS swine. Therapeutic use of this drug in patients with anaesthetic-induced malignant hyperpyrexia appears to be indicated. 

Figures and Tables from this paper

Effect of diltiazem on porcine malignant hyperpyrexia induced by suxamethonium and halothane.
TLDR
Diltiazem should not be considered to be an effective therapeutic agent for MH and should not displace the use of dantrolene.
Drug Treatment of Malignant Hyperpyrexia
TLDR
It is suggested that dantrolene sodium is the drug of choice for lowering the raised myoplasmic calcium concentrations in malignant hyperpyrexia.
The pathopharmacology of malignant hyperpyrexia.
A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.
TLDR
Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro and this reaction is now used as an additional screening test for the MHS phenotype.
The screening of atracurium in MHS swine.
TLDR
The potential role of atracurium besylate as a trigger or attenuator of the malignant hyperthermia syndrome was tested in six MHS Landrace swine and in no instance could the syndrome be triggered by atracuium nor did it convincingly attenuate the syndrome when triggered by halothane.
The chick as a model for malignant hyperpyrexia.
The effects of calcium channel blocking drugs on halothane initiation of malignant hyperthermia in MHS swine and on the established syndrome.
TLDR
Nifedipine alone caused attenuation of halothane-initiated malignant hyperthermia to the extent of blocking onset of the syndrome in 29% of animals for the 60 minute period of exposure.
The effects of calcium channel blocking drugs on halothane initiation of malignant hyperthermia in MHS swine and on the established syndrome.
TLDR
Nifedipine alone caused attenuation of halothane-initiated malignant hyperthermia to the extent of blocking onset of the syndrome in 29% of animals for the 60 minute period of exposure.
Ketanserin and malignant hyperthermia in pigs
TLDR
Four Danish landrace pigs susceptible to MH were challenged with halothane and suxamethonium on six occasions after pretreatment with the serotonin‐S2 antagonist ketanserin, and developed typical MH on all occasions despite the pretreatment.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Anaesthetic-induced Malignant Hyperpyrexia: A Suggested Method of Treatment
TLDR
Experiments in susceptible Landrace pigs have shown that procaine blocks the initiation of anaesthetic-induced malignant hyperpyrexia by both halothane and succinylcholine, and on the basis of these findings a treatment regimen can be suggested for patients who develop malignantHyperPyrexia.
Changes underlying Halothane-induced Malignant Hyperpyrexia in Landrace Pigs
TLDR
The onset of this phenomenon is rapid (10–15 min after administration of halothane) and there is extreme rigidity of skeletal muscles, a rapid rise in body temperature to 42°–45° C, severe acidosis and a fatal outcome in spite of cooling, muscle relaxants and intravenous alkalis.
Anaesthetic-induced malignant hyperpyrexia and a method for its prediction.
TLDR
The clinical syndrome of anaesthetic-triggered malignant hyperpyrexia occurring in pigs is described, and Halothane, chloroform and suxamethonium have been identified as triggering agents.
ANAESTHETIC-INDUCED MALIGNANT HYPERPYREXIA AND A METHOD FOR ITS PREDICTION
TLDR
The muscle of affected pigs shows, in comparison to normal pigs, an abnormal fall in ATP content in response to incubation an to “in vitro” exposure to halothane, which provides a method of predicting the development of the syndrome.
Malignant hyperpyrexia
TLDR
It is suggested that serum CPK estimations be used to screen pigs for selective breeding and so eliminate the disease, which causes soft exudative pork.
Dantrolene, a direct acting skeletal muscle relaxant.
TLDR
It is hypothesized that dantrolene causes skeletal muscle relaxation by a direct action on muscle at a site beyond the neuromuscular junction.
The Effects of Dantrolene Sodium on Spasticity and Motor Performance in Hemiplegia
Though this new drug decreases the activity of deep tendon reflexes, it seems to diminish gross strength. There was improvement in motor function of the upper extremities.
Dantrolene sodium for treatment of spasticity.
Dantrolene sodium in the treatment of spasticity.
Clinical pharmacophysiology of dantrolene sodium
  • Br. J. Anaesth.,
  • 1972
...
1
2
...