Malignant hyperthermia: a review

@inproceedings{Rosenberg2015MalignantHA,
  title={Malignant hyperthermia: a review},
  author={Henry Rosenberg and Neil A Pollock and Anja H. Schiemann and Terasa F Bulger and Kathryn M. Stowell},
  booktitle={Orphanet journal of rare diseases},
  year={2015}
}
Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stressors such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:10,000 to 1: 250,000 anesthetics. However, the prevalence of the genetic abnormalities may be as great as one in 400… CONTINUE READING
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