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DNA Alkylation

DNA Alkylation involves the addition of alkyl groups to any of several vulnerable positions on all four of the DNA bases. Alkylating agents can also… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little… Expand
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Review
2010
Review
2010
The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations that occur through DNA strand breaks are the precursors of the variety of genetic disorders including cancer. Life… Expand
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Highly Cited
2003
Highly Cited
2003
A 9-aminoacridine conjugate of a silyl-protected bis(acetoxymethyl)phenol (bisQMP) was synthesized and evaluated as an inducible… Expand
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Highly Cited
2002
Highly Cited
2002
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1… Expand
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Highly Cited
1999
Highly Cited
1999
SummaryThe anti-tumour drug treosulfan (L-threitol 1,4-bismethanesulphonate, Ovastat) is a prodrug for epoxy compounds by… Expand
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Highly Cited
1993
Highly Cited
1993
Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1… Expand
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Review
1990
Review
1990
Following the observation that N-methyl-N'nitro-N-nitrosoguanidine had antitumor activity against L1210 cells (Greene and… Expand
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Highly Cited
1990
Highly Cited
1990
We previously cloned a DNA fragment from Saccharomyces cerevisiae that suppressed the alkylation sensitivity of Escherichia coli… Expand
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Highly Cited
1988
Highly Cited
1988
The DNA alkylation and sequence specificity of a group of natural and synthetic pyrrolo-[1,4]benzodiazepines [P(1,4)Bs] were… Expand
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