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DNA Alkylation

DNA Alkylation involves the addition of alkyl groups to any of several vulnerable positions on all four of the DNA bases. Alkylating agents can also… 
National Institutes of Health

Related topics

Related topics

5 relations
Chromosome StructuresDNA Repairirofulvenpenclomedine

Papers overview

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Highly Cited
2008
Highly Cited
2008
Yatakemycin: total synthesis, DNA alkylation, and biological properties.
DNA-binding small molecules are an important source of anticancer therapeutics that display a diverse array of mechanisms of… 
Highly Cited
2005
Highly Cited
2005
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage.
Members of the RecQ family of DNA helicases, mutated in several syndromes associated with cancer predisposition, are key… 
Highly Cited
2003
Highly Cited
2003
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.
The mutagenic and cytotoxic effects of many endogenous and exogenous alkylating agents are mitigated by the actions of O(6… 
2002
2002
Palladium-catalyzed sequential alkylation-alkenylation reactions. Application to the synthesis of 2-substituted-4-benzoxepines and 2,5-disubstituted-4-benzoxepines.
The synthesis of 2-substituted-4-benzoxepines and 2,5-disubstituted-4-benzoxepines from aryl iodides and bromoenoates is… 
2002
2002
Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation.
New hairpin polyamide-CPI (CPI = cyclopropylpyrroloindole) conjugates, compounds 12-14, were synthesized and their DNA-alkylating… 
Highly Cited
2001
Highly Cited
2001
Thermodynamic versus kinetic products of DNA alkylation as modeled by reaction of deoxyadenosine.
Alkylating agents that react through highly electrophilic quinone methide intermediates often express a specificity for the… 
2001
2001
Thiol-independent DNA alkylation by leinamycin.
Covalent modification of cellular DNA can have profound biological consequences and, therefore, the mechanisms by which small… 
1996
1996
Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A.
Duocarmycin A (Duo) normally alkylates adenine N3 at the 3' end of A + T-rich sequences in DNA. The efficient adenine alkylation… 
1994
1994
Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction.
In this study, we have mapped the intracellular alkylation sites of adozelesin and bizelesin, two potent analogs of CC-1065, in… 
Highly Cited
1988
Highly Cited
1988
GC-rich regions in genomes as targets for DNA alkylation.
For many DNA-damaging agents, the extent of damage at any given base site is influenced by the DNA sequence surrounding that site… 
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