DNA Alkylation

DNA Alkylation involves the addition of alkyl groups to any of several vulnerable positions on all four of the DNA bases. Alkylating agents can also… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2018
0204019682018

Papers overview

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2011
2011
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little… (More)
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Highly Cited
2002
Highly Cited
2002
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1… (More)
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1999
1999
SummaryThe anti-tumour drug treosulfan (L-threitol 1,4-bismethanesulphonate, Ovastat) is a prodrug for epoxy compounds by… (More)
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1996
1996
The single cell gel electrophoresis (SCGE) or comet assay, which measures DNA strand breaks in individual cells, was used to… (More)
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1994
1994
The Escherichia coli Ada and Ogt DNA methyltransferases (MTases) are known to transfer simple alkyl groups from O6-alkylguanine… (More)
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1993
Highly Cited
1993
Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1… (More)
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1990
1990
We previously cloned a DNA fragment from Saccharomyces cerevisiae that suppressed the alkylation sensitivity of Escherichia coli… (More)
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1986
1986
After anaerobic reductive activation by either NADPH cytochrome P-450 reductase (EC 1.6.2.4) or xanthine oxidase (EC 1.2.3.2… (More)
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1986
1986
The ada-alkB operon protects Escherichia coli against the effects of many alkylating agents. We have subcloned it into the pSV2… (More)
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1979
1979
A simple fluorescence assay was devised to measure alkylation of guanine. The assay was tested with simple epoxides: propylene… (More)
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