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Aminoglycoside antibiotics induce bacterial biofilm formation
TLDR
It is shown that subinhibitory concentrations of aminoglycoside antibiotics induce biofilm formation in P. aeruginosa and Escherichia coli, and the molecular basis of this response includes alterations in the level of c-di-GMP.
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
TLDR
The folding structure of the human telomeric sequence in K+ solution determined by NMR demonstrates a novel, unprecedented intramolecular G-quadruplex folding topology with hybrid-type mixed parallel/antiparallel G-strands, and suggests a straightforward pathway for the secondary structure formation with effective packing within the extended human telomersic DNA.
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
TLDR
The distinct major BCL2 promoter G-quadruplex structure suggests that it can be specifically involved in gene modulation and can be an attractive target for pathway-specific drug design.
Structural basis of HIV-1 resistance to AZT by excision
Human immunodeficiency virus (HIV-1) develops resistance to 3′-azido-2′,3′-deoxythymidine (AZT, zidovudine) by acquiring mutations in reverse transcriptase that enhance the ATP-mediated excision of
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
TLDR
The first structure of the major intramolecular G-quadruplex formed in a native, non-modified human telomeric sequence in K+ solution is reported, a hybrid-type mixed parallel/antiparallel-G-stranded G- quadruplex, one end of which is covered by a novel T:A:T triple capping structure.
A glutamate‐alanine‐leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP
TLDR
Besides its known role in regulating cellulose synthesis and biofilm formation, bacterial c‐diGMP also regulates host–pathogen interactions involving antioxidant defence and cytotoxicity.
Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry.
TLDR
Interstrand and intrastrand DNA-DNA cross-linking by individual DEB stereoisomers was investigated by PAGE, mass spectrometry, and stable isotope labeling and revealed that S,S-DEB produced the highest number of interchain cross-links in 5'-GGC-3'/3'-CCG-5' sequences.
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
TLDR
The first solution structure of a G-quadruplex found to form in the promoter region of an oncogene (c- MYC) is reported, with a similar melting temperature to that of the wild-type 27-mer purine-rich NHE III(1) sequence of the c-MYC promoter.
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