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All CG dinucleotides along exons 5-8 of the p53 tumor suppressor gene contain endogenous 5-methylcytosine (MeC). These same sites (e.g., codons 157, 158, 245, 248, and 273) are mutational hot spots(More)
The architecture of G-G-G-G tetrad-aligned DNA quadruplexes in monovalent cation solution is dependent on the directionality of the four strands, which in turn are defined by loop connectivities and(More)
Peroxynitrite is a strong oxidizing agent that is formed in the reaction of nitric oxide and superoxide anion. It is capable of oxidizing and nitrating a variety of biological targets including DNA,(More)
We report the first examples of the specifically 15N and 13C multilabeled nucleosides:  [1,NH2-15N2]-and [2-13C-1,NH2-15N2-]-guanosine; [1,7,NH2-15N3]- and [2-13C-1,7,NH2-15N3]-2‘-deoxyguanosine. In(More)