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DNA Adducts

Known as: Drug-DNA Adduct, Carcinogen-DNA Adducts, DNA Adduct 
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
National Institutes of Health

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7,12-dimethylbenz(a)anthracene-DNA adduct8-methoxypsoralen-DNAN-hydroxy-2-naphthylamine DNA adductaflatoxin B1-DNA adduct
In BloodMutagensProcess of secretionagonists

Papers overview

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Highly Cited
2008
Highly Cited
2008
Metal atoms collinear with the spiro carbon of 6,6-open adducts, M2@C80(Ad) (M = La and Ce, Ad = adamantylidene).
The photochemical reaction of M2@C80 (M = La and Ce) with 2-adamantane-2,3'-[3H]-diazirine (1) affords the corresponding adducts… 
Highly Cited
2005
Highly Cited
2005
The first fulleropyrrolidine derivative of Sc3N@C80: pronounced chemical shift differences of the geminal protons on the pyrrolidine ring.
The first pyrrolidine adduct on Sc(3)N@C(80) was synthesized and fully characterized. Addition of the N-ethylazomethine ylide… 
Highly Cited
1999
Highly Cited
1999
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been… 
Highly Cited
1996
Highly Cited
1996
Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2'-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality.
We have used a site-specific approach to investigate the mutagenic potential of (+)- and (-)-trans-anti-benzo[a]pyrene diol… 
Highly Cited
1995
Highly Cited
1995
Induction by estrogens of lipid peroxidation and lipid peroxide-derived malonaldehyde-DNA adducts in male Syrian hamsters: role of lipid peroxidation in estrogen-induced kidney carcinogenesis.
Estrogen-induced kidney carcinogenesis in male Syrian hamsters has previously been postulated to be mediated by free radicals… 
Highly Cited
1995
Highly Cited
1995
Styrene oxide-induced HPRT mutations, DNA adducts and DNA strand breaks in cultured human lymphocytes.
Styrene-7,8-oxide (SO) is the major in vivo metabolite of styrene, a widely used plastic monomer. SO has been classified as… 
Highly Cited
1994
Highly Cited
1994
Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles.
Exposure of rats to diesel emissions results in the development of lung tumors. The objective of this study was to determine… 
Highly Cited
1992
Highly Cited
1992
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens.
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… 
Highly Cited
1988
Highly Cited
1988
32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures.
A 32P-adduct assay for the measurement of low levels (1 adduct per 10(7) nucleotides) of binding of carcinogens to DNA has been… 
Highly Cited
1977
Highly Cited
1977
Detection of carcinogen–DNA adducts by radioimmunoassay
COVALENT binding of carcinogen to nucleic acids is believed to be an essential component of the carcinogenic process1, so it is… 
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