DNA (Cytosine-5)-Methyltransferase 3A

Known as: DNA Methyltransferase HsaIIIA, M.HsaIIIA, DNMT3A 
DNA (cytosine-5)-methyltransferase 3A protein (909 aa, ~102 kDa) is encoded by the human DNMT3A gene. This soluble, nuclear protein is involved in… (More)
National Institutes of Health

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7 relations
Cell NucleusDNA MethylationDNMT3A geneEnzyme Gene
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The… (More)
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Highly Cited
2011
Highly Cited
2011
DNMT3A mutations in acute myeloid leukemia
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA… (More)
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Highly Cited
2011
Highly Cited
2011
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells obstructs differentiation; however, the role… (More)
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Highly Cited
2010
Highly Cited
2010
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic neurons, but their function in the CNS is… (More)
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Highly Cited
2007
Highly Cited
2007
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in… (More)
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Highly Cited
2004
Highly Cited
2004
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
Imprinted genes are epigenetically marked during gametogenesis so that they are exclusively expressed from either the paternal or… (More)
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Highly Cited
2003
Highly Cited
2003
Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin
BACKGROUND Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are characteristic hallmarks of mammalian heterochromatin… (More)
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Highly Cited
1999
Highly Cited
1999
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
The establishment of DNA methylation patterns requires de novo methylation that occurs predominantly during early development and… (More)
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Highly Cited
1999
Highly Cited
1999
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have… (More)
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Highly Cited
1998
Highly Cited
1998
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
nature genetics volume 19 july 1998 219 De novo methylation of genomic DNA is a developmentally regulated process that is… (More)
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