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DNA (Cytosine-5)-Methyltransferase 3A

Known as: DNA Methyltransferase HsaIIIA, M.HsaIIIA, DNMT3A 
DNA (cytosine-5)-methyltransferase 3A protein (909 aa, ~102 kDa) is encoded by the human DNMT3A gene. This soluble, nuclear protein is involved in… 
National Institutes of Health

Related topics

Related topics

7 relations
Cell NucleusDNA MethylationDNMT3A geneEnzyme Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice
Highly Cited
2014
Highly Cited
2014
Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes
Alcohol exposure affects neuronal plasticity in the adult and developing brain. Astrocytes play a major role in modulating… 
2013
2013
Structural basis for recognition of H 3 K 4 methylation status by the DNA methyltransferase 3 A ATRX – DNMT 3 – DNMT 3 L domain
DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in… 
Highly Cited
2012
Highly Cited
2012
MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer
Purpose: Overexpression of DNA 5′-cytosine-methyltransferase 3A (DNMT3A), which silences genes including tumor suppressor genes… 
Highly Cited
2006
Highly Cited
2006
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.
DNA methylation is a major epigenetic mechanism that has been suggested to control developmental gene regulation during… 
Highly Cited
2006
Highly Cited
2006
CpG Sites Preferentially Methylated by Dnmt3a in Vivo*
Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals. It has been shown… 
Highly Cited
2002
Highly Cited
2002
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.
Highly Cited
2002
Highly Cited
2002
Role of de Novo DNA Methyltransferases and Methyl CpG-binding Proteins in Gene Silencing in a Rat Hepatoma*
The expression of metallothionein-I (MT-I), a known antioxidant, was suppressed in a transplanted rat hepatoma because of… 
Highly Cited
2001
Highly Cited
2001
Protein Binding Protects Sites on Stable Episomes and in the Chromosome from De Novo Methylation
ABSTRACT We have utilized the Escherichia coli lacrepressor-operator system to test whether protein binding can interfere with de… 
Review
2001
Review
2001
Lashings of DNA methylation, forkfuls of chromatin remodeling.
Epigenetic control of gene expression in animals and plants is often correlated with changes in cytosine methylation at specific… 
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