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DNA (Cytosine-5)-Methyltransferase 3A
Known as:
DNA Methyltransferase HsaIIIA
, M.HsaIIIA
, DNMT3A
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DNA (cytosine-5)-methyltransferase 3A protein (909 aa, ~102 kDa) is encoded by the human DNMT3A gene. This soluble, nuclear protein is involved in…
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National Institutes of Health
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Related topics
Related topics
7 relations
Cell Nucleus
DNA Methylation
DNMT3A gene
Enzyme Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice
Shivakumar Subbanna
,
Nagaraja N. Nagre
,
+4 authors
B. Basavarajappa
Neuroscience
2014
Corpus ID: 45193668
Highly Cited
2014
Highly Cited
2014
Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes
Xiaolu Zhang
,
H. Kusumo
,
A. Sakharkar
,
S. Pandey
,
M. Guizzetti
Journal of Neurochemistry
2014
Corpus ID: 206089789
Alcohol exposure affects neuronal plasticity in the adult and developing brain. Astrocytes play a major role in modulating…
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2013
2013
Structural basis for recognition of H 3 K 4 methylation status by the DNA methyltransferase 3 A ATRX – DNMT 3 – DNMT 3 L domain
Junji Otani
,
Toshiyuki Nankumo
,
K. Arita
,
S. Inamoto
,
M. Ariyoshi
,
M. Shirakawa
2013
Corpus ID: 38785182
DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in…
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Highly Cited
2012
Highly Cited
2012
MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer
Yen-An Tang
,
Ruo-Kai Lin
,
+4 authors
Yi-Ching Wang
Clinical Cancer Research
2012
Corpus ID: 5578022
Purpose: Overexpression of DNA 5′-cytosine-methyltransferase 3A (DNMT3A), which silences genes including tumor suppressor genes…
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Highly Cited
2006
Highly Cited
2006
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.
M. Oda
,
A. Yamagiwa
,
+6 authors
M. Okano
Genes & Development
2006
Corpus ID: 5648692
DNA methylation is a major epigenetic mechanism that has been suggested to control developmental gene regulation during…
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Highly Cited
2006
Highly Cited
2006
CpG Sites Preferentially Methylated by Dnmt3a in Vivo*
M. Oka
,
N. Rodić
,
Jamie Graddy
,
Lung-Ji Chang
,
N. Terada
Journal of Biological Chemistry
2006
Corpus ID: 21512937
Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for embryonic development in mammals. It has been shown…
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Highly Cited
2002
Highly Cited
2002
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.
J. E. Dodge
,
B. Ramsahoye
,
Z. Wo
,
M. Okano
,
E. Li
Gene
2002
Corpus ID: 40267966
Highly Cited
2002
Highly Cited
2002
Role of de Novo DNA Methyltransferases and Methyl CpG-binding Proteins in Gene Silencing in a Rat Hepatoma*
S. Majumder
,
K. Ghoshal
,
+5 authors
S. Jacob
Journal of Biological Chemistry
2002
Corpus ID: 22056023
The expression of metallothionein-I (MT-I), a known antioxidant, was suppressed in a transplanted rat hepatoma because of…
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Highly Cited
2001
Highly Cited
2001
Protein Binding Protects Sites on Stable Episomes and in the Chromosome from De Novo Methylation
Li Han
,
I. G. Lin
,
C. Hsieh
Molecular and Cellular Biology
2001
Corpus ID: 10830217
ABSTRACT We have utilized the Escherichia coli lacrepressor-operator system to test whether protein binding can interfere with de…
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Review
2001
Review
2001
Lashings of DNA methylation, forkfuls of chromatin remodeling.
R. Meehan
,
S. Pennings
,
I. Stancheva
Genes & Development
2001
Corpus ID: 35952053
Epigenetic control of gene expression in animals and plants is often correlated with changes in cytosine methylation at specific…
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