DNA (Cytosine-5)-Methyltransferase 3A

Known as: DNA Methyltransferase HsaIIIA, M.HsaIIIA, DNMT3A 
DNA (cytosine-5)-methyltransferase 3A protein (909 aa, ~102 kDa) is encoded by the human DNMT3A gene. This soluble, nuclear protein is involved in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The… (More)
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Highly Cited
2011
Highly Cited
2011
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA… (More)
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Highly Cited
2011
Highly Cited
2011
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells obstructs differentiation; however, the role… (More)
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Highly Cited
2010
Highly Cited
2010
Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic neurons, but their function in the CNS is… (More)
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Highly Cited
2007
Highly Cited
2007
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in… (More)
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Highly Cited
2004
Highly Cited
2004
Imprinted genes are epigenetically marked during gametogenesis so that they are exclusively expressed from either the paternal or… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are characteristic hallmarks of mammalian heterochromatin… (More)
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Highly Cited
1999
Highly Cited
1999
The establishment of DNA methylation patterns requires de novo methylation that occurs predominantly during early development and… (More)
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Highly Cited
1999
Highly Cited
1999
DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have… (More)
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Highly Cited
1998
Highly Cited
1998
nature genetics volume 19 july 1998 219 De novo methylation of genomic DNA is a developmentally regulated process that is… (More)
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