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  • Influence
Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism
The treatment of alcoholism requires the proper management of ethanol withdrawal symptoms, such as anxiety, to prevent further alcohol use and abuse. In this study, we investigated the potential roleExpand
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Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism.
We investigated the role of cAMP-responsive element-binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferring (NP)Expand
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The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure.
  • A. Roy, S. Pandey
  • Medicine, Psychology
  • Alcoholism, clinical and experimental research
  • 1 June 2002
BACKGROUND Neuropeptide Y (NPY) has been implicated in the alcohol-drinking behaviors of rodents. This study investigated the possible involvement of NPY in the neuroadaptational mechanisms toExpand
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Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims.
OBJECTIVE Abnormalities of serotonin (5-HT) receptor subtypes have been observed in the postmortem brains of adult suicide victims; however, their role in teenage suicide is unexplored. The authorsExpand
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Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain
Addiction to nicotine may result in molecular adaptations in the neurocircuitry of specific brain structures via changes in the cyclic AMP‐responsive element binding protein (CREB)‐dependent geneExpand
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Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene.
  • S. Pandey
  • Medicine
  • Trends in pharmacological sciences
  • 1 September 2003
It has been hypothesized that anxiety disorders play an important role in the initiation and maintenance of alcohol drinking behaviors. However, the molecular mechanisms for the association betweenExpand
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Neuroscience of alcoholism: molecular and cellular mechanisms
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of theExpand
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Potential role of the gene transcription factor cyclic AMP-responsive element binding protein in ethanol withdrawal-related anxiety.
This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) geneExpand
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Partial Deletion of the cAMP Response Element-Binding Protein Gene Promotes Alcohol-Drinking Behaviors
The cAMP response element-binding protein (CREB) gene transcription factor has been shown to play a role in the synaptic plasticity associated with drug addictive behaviors; however, the causal roleExpand
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Effector Immediate-Early Gene Arc in the Amygdala Plays a Critical Role in Alcoholism
The immediate early gene, activity-regulated cytoskeleton-associated protein (Arc), has been implicated in synaptic plasticity. However, the role of Arc in alcoholism is unknown. Here, we report thatExpand
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