DNA Methylation

Known as: Methylation, DNA, DNA Methylation Process, DNA Methylations 
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.

Topic mentions per year

Topic mentions per year

1969-2017
05001000150019692017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
We have developed a new generation of genome-wide DNA methylation BeadChip which allows high-throughput methylation profiling of… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Although it is known that the methylation of DNA in 5' promoters suppresses gene expression, the role of DNA methylation in gene… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of active genes, and the extent of… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. Our knowledge… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Cytosine DNA methylation is important in regulating gene expression and in silencing transposons and other repetitive sequences… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Cytosine methylation, a common form of DNA modification that antagonizes transcription, is found at transposons and repeats in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND Histone H3 lysine 9 (H3-K9) methylation and DNA methylation are characteristic hallmarks of mammalian heterochromatin… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates. Aberrant methylation of CpG islands in… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
We report here on a quantitative technique called COBRA to determine DNA methylation levels at specific gene loci in small… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1980
Highly Cited
1980
The nucleoside analog 5-azacytidine (5-aza-CR) induced marked changes in the differentiated state of cultured mouse embryo cells… (More)
Is this relevant?