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DKC1 gene

Known as: H/ACA ribonucleoprotein complex subunit 4, NOPP140-ASSOCIATED PROTEIN, 57-KD, XAP101 
This gene is involved in both H/ACA small nucleolar RNA ribonucleoprotein assembly and telomerase stabilization and maintenance.
National Institutes of Health

Related topics

Related topics

6 relations
DKC1 protein, humanH/ACA Ribonucleoprotein Complex Subunit 4, humanLigand BindingRNA Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs.
Alu repetitive sequences are the most abundant short interspersed DNA elements in the human genome. Full-length Alu elements are… 
2011
2011
Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.
2011
2011
Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment
Mutations in DKC1, encoding telomerase associated protein dyskerin, cause X‐linked dyskeratosis congenita (DC), a bone marrow (BM… 
Highly Cited
2009
Highly Cited
2009
Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP.
Dyskeratosis congenita (DC) is an inherited disorder that implicates defects in the biology of telomeres, which are maintained by… 
2008
2008
Trypanosome Spliced-Leader-Associated RNA (SLA1) Localization and Implications for Spliced-Leader RNA Biogenesis
ABSTRACT Spliced-leader-associated RNA (SLA1) guides the pseudouridylation at position −12 (relative to the 5′ splice site) of… 
2008
2008
An intronic mutation in DKC1 in an infant with Høyeraal–Hreidarsson syndrome
Toni Pearson, Fiona Curtis, Ayman Al-Eyadhy, Salem Al-Tamemi, Bruce Mazer, Yigal Dror, Sharon Abish, Sherri Bale, John Compton… 
2007
2007
DKC1 is a direct and conserved transcriptional target of c-MYC.
2007
2007
Dynamic interactions within sub-complexes of the H/ACA pseudouridylation guide RNP
H/ACA RNP complexes change uridines to pseudouridines in target non-coding RNAs in eukaryotes and archaea. H/ACA RNPs are… 
2006
2006
Archaeal pre-mRNA splicing: a connection to hetero-oligomeric splicing endonuclease.
2003
2003
Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II).
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