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H/ACA Ribonucleoprotein Complex Subunit 4, human

Known as: H/ACA Ribonucleoprotein Complex Subunit 4, Nucleolar Protein NAP57, NOPP140-Associated Protein, 57-kD 
H/ACA ribonucleoprotein complex subunit 4 (514 aa, ~58 kDa) is encoded by the human DKC1 gene. This protein is involved in telomerase stabilization… 
National Institutes of Health

Related topics

Related topics

6 relations
Cell NucleolusDKC1 geneLigand BindingRNA Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation
Abstract The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo… 
Review
2016
Review
2016
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms
Chromosome-shortening is characteristic of normal cells, and is known as the end replication problem. Telomerase is the enzyme… 
Review
2014
Review
2014
Human dyskerin: beyond telomeres
Abstract Human dyskerin is an evolutively conserved protein that participates in diverse nuclear complexes: the H/ACA snoRNPs… 
2014
2014
Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis
The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting… 
2014
2014
Expression of the Genetic Suppressor Element 24.2 (GSE24.2) Decreases DNA Damage and Oxidative Stress in X-Linked Dyskeratosis Congenita Cells
The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein… 
2013
2013
Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin
Highly Cited
2006
Highly Cited
2006
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita.
Dyskeratosis congenita (DC) patients suffer a progressive and ultimately fatal loss of hematopoietic renewal correlating with… 
Highly Cited
2006
Highly Cited
2006
Dyskerin expression influences the level of ribosomal RNA pseudo‐uridylation and telomerase RNA component in human breast cancer
Dyskerin is a nucleolar protein, altered in dyskeratosis congenita, which carries out two separate functions, both fundamental… 
2002
2002
Increased mortality rate and not impaired ribosomal biogenesis is responsible for proliferative defect in dyskeratosis congenita cell lines.
X-linked dyskeratosis congenita is a rare inherited disorder mainly characterized by progressive changes in proliferating… 
2000
2000
Gene structure and expression of the mouse dyskeratosis congenita gene, dkc1.
Mutations in the DKC1 gene are responsible for causing X-linked recessive dyskeratosis congenita (DKC) and a more severe allelic… 
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