• Publications
  • Influence
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal
TLDR
Fluorescence in situ hybridization demonstrates that in HeLa cancer cells, human telomerase RNA (hTR) accumulates in the nucleoplasmic Cajal bodies (CBs).
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
TLDR
It is reported that in human HeLa cells more than half of the P-TEFb is sequestered in larger complexes that also contain 7SK RNA, an abundant, small nuclear RNA of hitherto unknown function, which may contribute to an important feedback loop modulating the activity of RNA Pol II.
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation.
TLDR
Nine novel human ACA snoRNAs (U64-U72) are characterized, demonstrating that these RNAs possess closely related nucleolar functions and sharing a common secondary structure and conserved box elements that likely function as binding sites for common proteins.
Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm
TLDR
Evidence is provided supporting the notion that modification of Sm snRNAs occurs in nucleoplasmic Cajal bodies (CBs), where modification guide RNAs accumulate, and that p80 coilin, the CB marker protein, is not required for snRNA modification.
Cajal body‐specific small nuclear RNAs: a novel class of 2′‐O‐methylation and pseudouridylation guide RNAs
TLDR
The results provide strong support for the idea that the Cajal body, this mysterious nuclear organelle, provides the cellular locale for post‐transcriptional modification of spliceosomal snRNAs.
Function and synthesis of small nucleolar RNAs.
...
...