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DEFB1 gene

Known as: DEFB-1, HBD1, beta defensin 1 
This gene is involved in mitigating host inflammatory defense mechanisms in response to microbial invasion.
National Institutes of Health

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12 relations
Cystic FibrosisDEFA10P geneDEFB1 protein, humanDEFB103A gene

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DEFB1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors.
2012
2012
Immune defense single nucleotide polymorphisms and recruitment strategies associated with contact lens keratitis.
2009
2009
Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn’s disease
Background  Crohn’s Disease (CD), a chronic intestinal inflammation, is currently treated primarily by therapeutics which are… 
2008
2008
Human α- and β-Defensins Bind to Immobilized Adhesins from Porphyromonas gingivalis
ABSTRACT Human neutrophil peptide α-defensins (HNPs) and human β-defensins (HBDs) are small well-characterized peptides with… 
2007
2007
Genomic variations within DEFB1 are associated with the susceptibility to and the fatal outcome of severe sepsis in Chinese Han population
Sepsis is a systemic inflammatory response syndrome to infection. Human β-defensin 1 (DEFB1) is a multifunctional mediator in… 
Highly Cited
2006
Highly Cited
2006
Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children
Human β-defensin (HBD)-1 is constitutively expressed in the airway, and hBD-1 plays crucial roles in innate immunity against… 
2005
2005
Enhanced Human β-Defensin-2 (hBD-2) Expression by Corticosteroids Is Independent of NF-κB in Colonic Epithelial Cells (CaCo2)
Abstractβ-Defensins are small cationic peptides with antimicrobial properties that contribute to innate host defense. Unlike… 
2003
2003
Evolution of the beta defensin 2 gene in primates
With the aim of further investigating the molecular evolution of beta defensin genes, after having analysed beta defensin 1… 
2001
2001
Expression of inflammatory cytokines and beta-defensin 1 mRNAs in porcine epithelial rests of Malassez in vitro
In the present study, we investigated the mRNA expression of inflammatory cytokines, including interleukin (IL)-1α, IL-6, IL-8… 
Highly Cited
1998
Highly Cited
1998
Mouse beta defensin-1 is a functional homolog of human beta defensin-1
Abstract. Defensin are 3–4 kDa antimicrobial peptides of which three distinct families have been identified; α-defensin… 
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