DEFB103A gene

Known as: beta defensin-3, DEFB-3, DEFENSIN, BETA, 3, FORMERLY 
This gene is involved in the microbicidal and cytotoxic activity of neutrophils.
National Institutes of Health

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Antimicrobial EffectBeta-Defensin 103DEFB1 geneDEFB103B gene
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DEFB103A wt Allele

Papers overview

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Review
2013
Review
2013
Correlating multiallelic copy number polymorphisms with disease susceptibility.
The human genome contains a significant amount of sequence variation, from single nucleotide polymorphisms to large stretches of… (More)
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2010
2010
Human β-defensin 3 has immunosuppressive activity in vitro and in vivo
Beta-defensins are antimicrobial peptides with an essential role in the innate immune response. In addition beta-defensins can… (More)
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Highly Cited
2009
Highly Cited
2009
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although… (More)
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Highly Cited
2007
Highly Cited
2007
Gram-positive three-component antimicrobial peptide-sensing system.
To survive during colonization or infection of the human body, microorganisms must circumvent mechanisms of innate host defense… (More)
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Highly Cited
2006
Highly Cited
2006
Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4.
Previously, we showed that human epithelial cell-derived beta-defensins (hBD)-2 and -3 block HIV-1 replication via a direct… (More)
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Highly Cited
2005
Highly Cited
2005
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.
To investigate defensin gene copy number polymorphisms, a quantitative real-time PCR assay was developed and used to study DNA… (More)
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Highly Cited
2003
Highly Cited
2003
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Human defensins form a family of small, cationic, and Cys-rich antimicrobial proteins that play important roles in innate… (More)
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Highly Cited
2003
Highly Cited
2003
Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.
Using a combination of multiplex amplifiable probe hybridization and semiquantitative fluorescence in situ hybridization (SQ-FISH… (More)
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Highly Cited
2001
Highly Cited
2001
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of…
Previous studies have shown the implication of beta-defensins in host defense of the human body. The human beta-defensins 1 and 2… (More)
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Highly Cited
1999
Highly Cited
1999
Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.
One component of host defense at mucosal surfaces is epithelium-derived peptides with antimicrobial activity called defensins. We… (More)
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