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DEFB103A gene

Known as: beta defensin-3, DEFB-3, DEFENSIN, BETA, 3, FORMERLY 
This gene is involved in the microbicidal and cytotoxic activity of neutrophils.
National Institutes of Health

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Related topics

9 relations
Antimicrobial EffectBeta-Defensin 103DEFB1 geneDEFB103B gene
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DEFB103A wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although… Expand
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Highly Cited
2009
Highly Cited
2009
Differential innate immune responses of a living skin equivalent model colonized by Staphylococcus epidermidis or Staphylococcus aureus.
Staphylococcus epidermidis is a commensal on skin, whereas Staphylococcus aureus is a transient pathogen. The aim was to… Expand
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Highly Cited
2008
Highly Cited
2008
Evaluation of the inhibitory effects of human serum components on bactericidal activity of human beta defensin 3
Naturally occurring cationic antimicrobial peptides (CAPs) are an essential component of the innate immune system of… Expand
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Highly Cited
2007
Highly Cited
2007
Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must circumvent mechanisms of innate host defense… Expand
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Highly Cited
2007
Highly Cited
2007
Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils.
BACKGROUND AND OBJECTIVE The aim of this study was to compare the susceptibility of nonperiodontopathic and periodontopathic… Expand
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Highly Cited
2006
Highly Cited
2006
In Vitro Bactericidal Activity of Human β-Defensin 3 against Multidrug-Resistant Nosocomial Strains
ABSTRACT The antimicrobial activity of human β-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus… Expand
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Highly Cited
2003
Highly Cited
2003
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3
  • Z. Wu, D. M. Hoover, +5 authors W. Lu
  • Proceedings of the National Academy of Sciences…
  • 2003
    • Corpus ID: 20105839
Human defensins form a family of small, cationic, and Cys-rich antimicrobial proteins that play important roles in innate… Expand
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Highly Cited
2003
Highly Cited
2003
Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.
Using a combination of multiplex amplifiable probe hybridization and semiquantitative fluorescence in situ hybridization (SQ-FISH… Expand
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Highly Cited
2001
Highly Cited
2001
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of…
Previous studies have shown the implication of beta-defensins in host defense of the human body. The human beta-defensins 1 and 2… Expand
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Highly Cited
1999
Highly Cited
1999
Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs
ABSTRACT One component of host defense at mucosal surfaces is epithelium-derived peptides with antimicrobial activity called… Expand
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