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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
  • K. Brogden
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 27 February 2005
Antimicrobial peptides are an abundant and diverse group of molecules that are produced by many tissues and cell types in a variety of invertebrate, plant and animal species. Their amino acidExpand
Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs
Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis (CF), we still lack answers to many questions about the pathogenesis of the disease, and it remains incurable.Expand
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
The lungs of just-born piglets with cystic fibrosis fail to efficiently eliminate bacteria, suggesting that lung problems in cystic fibrosis patients may be secondary to impaired antibacterialExpand
Antimicrobial peptides in animals and their role in host defences.
Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in responseExpand
Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken
ABSTRACT Gallinacin-3 and gallopavin-1 (GPV-1) are newly characterized, epithelial β-defensins of the chicken (Gallus gallus) and turkey (Meleagris gallopavo), respectively. In normal chickens, theExpand
Pasteurella haemolytica complicated respiratory infections in sheep and goats.
Respiratory infections which commonly occur in sheep and goats often result from adverse physical and physiological stress combined with viral and bacterial infections. Inevitably, PasteurellaExpand
Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice
Significance Middle East respiratory syndrome, caused by a zoonotically transmitted coronavirus (MERS-CoV), has a high mortality (∼36%). Because of limited autopsy data on tissues from MERSExpand
Response of the ruminant respiratory tract to Mannheimia (Pasteurella) haemolytica.
Pneumonia is a leading cause of loss to the sheep and cattle industry throughout the world. Mannheimia (Pasteurella) haemolytica is one of the most important respiratory pathogens of domesticExpand
Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis.
AIM The aim of this study was to compare the expression of 22 chemokines and cytokines in gingival crevicular fluid (GCF) from smokers and non-smokers with periodontitis and periodontally healthyExpand
Human polymicrobial infections
Summary Context Polymicrobial diseases, caused by combinations of viruses, bacteria, fungi, and parasites, are being recognisedExpand