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DEFB1 protein, human

Known as: hBD-1 protein, human, Beta-Defensin 1, Beta Defensin 1 
Beta-defensin 1 (68 aa, ~7 kDa) is encoded by the human DEFB1 gene. This protein is involved in chemotaxis and has bactericidal activity.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Anti-Infective Agentsbeta-Defensins
DEFB1 geneDEFB1 wt AlleleHomo sapiensImmune System Processes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Innate immunity in human bone.
Highly Cited
2006
Highly Cited
2006
Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children
Human β-defensin (HBD)-1 is constitutively expressed in the airway, and hBD-1 plays crucial roles in innate immunity against… 
2006
2006
Localization of antimicrobial peptides in normal and burned skin.
Highly Cited
2003
Highly Cited
2003
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status
Background/Aims: Recent reports have suggested that Helicobacter pylori infection induces the mucosal antibiotic peptide human… 
2003
2003
A study of host defence peptide beta-defensin 3 in primates.
We have investigated the molecular evolution of the gene coding for beta-defensin 3 (DEFB103) in 17 primate species including… 
Review
2000
Review
2000
A novel murine beta -defensin expressed in tongue, esophagus, and trachea.
beta-Defensins are broad spectrum antimicrobial peptides expressed at epithelial surfaces. Two human beta-defensins, HBD-1 and… 
Highly Cited
1999
Highly Cited
1999
Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy.
Epithelial cells have been to participate actively in host defense by producing small cationic peptides called defensins. To… 
Highly Cited
1999
Highly Cited
1999
Expression of beta-defensin genes by human salivary glands.
This study investigated expression of genes encoding human beta-defensins 1 and 2 by human salivary glands. Tissues from surgical… 
Highly Cited
1998
Highly Cited
1998
Mouse beta defensin-1 is a functional homolog of human beta defensin-1
Abstract. Defensin are 3–4 kDa antimicrobial peptides of which three distinct families have been identified; α-defensin… 
Highly Cited
1997
Highly Cited
1997
The mouse genome encodes a single homolog of the antimicrobial peptide human β‐defensin 1
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