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DAG/PE-Binding Domain

Known as: C1 Domain, Diacylglycerol Binding Domain, Phorbol Ester Binding Domain 
The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the… 
National Institutes of Health

Related topics

Related topics

16 relations
BRAF protein, humanChimerin 1Diacylglycerol Kinase AlphaDiacylglycerol Kinase Eta, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis
At the end of cell division, cytokinesis splits the cytoplasm of nascent daughter cells and partitions segregated sister genomes… 
Review
2008
Review
2008
Spatiotemporal dynamics of lipid signaling: Protein kinase C as a paradigm
The lipid second messenger diacylglycerol (DAG) controls the rate, amplitude, duration, and location of protein kinase C (PKC… 
Highly Cited
2008
Highly Cited
2008
PKCγ mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling
Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disorder caused by mutations in the neuronal-specific protein… 
Highly Cited
2007
Highly Cited
2007
A Single Residue in the C1 Domain Sensitizes Novel Protein Kinase C Isoforms to Cellular Diacylglycerol Production*
The C1 domain mediates the diacylglycerol (DAG)-dependent translocation of conventional and novel protein kinase C (PKC) isoforms… 
Highly Cited
2004
Highly Cited
2004
Structural Mechanism for Lipid Activation of the Rac-Specific GAP, β2-Chimaerin
Highly Cited
2002
Highly Cited
2002
Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα*
Phorbol esters, the archetypical (PKC) activators, induce apoptosis in androgen-sensitive LNCaP prostate cancer cells. In this… 
Highly Cited
2001
Highly Cited
2001
Phorbol esters modulate the Ras exchange factor RasGRP3.
RasGRP represents the prototype of a new class of guanine nucleotide exchange factors that activate small GTPases. The guanyl… 
Highly Cited
2000
Highly Cited
2000
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.
RasGRP is a recently described guanine nucleotide exchange factor (GEF) that possesses a single C1 domain homologous to that of… 
Highly Cited
1999
Highly Cited
1999
Interplay of C1 and C2 Domains of Protein Kinase C-α in Its Membrane Binding and Activation*
The regulatory domain of conventional protein kinase C (PKC) contains two membrane-targeting modules, the C2 domain that is… 
Highly Cited
1994
Highly Cited
1994
A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.
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