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Cytochrome P450 Family 46

Known as: Cytochrome P-450 CYP46, Cytochrome P450 Family 46 [Chemical/Ingredient], Cytochrome P 450 CYP46 
A cytochrome P450 enzyme family that includes CHOLESTEROL 24-HYDROXYLASE, which is expressed primarily in the brain and functions in CHOLESTEROL… 
National Institutes of Health

Related topics

Related topics

10 relations
CYP46A1 geneIn BloodProcess of secretionantagonists & inhibitors

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cholesterol 24-hydroxylase

Papers overview

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2010
2010
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury
Highly Cited
2008
Highly Cited
2008
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.
In traumatic brain injury (TBI), cellular loss from initial impact as well as secondary neurodegeneration leads to increased… 
Highly Cited
2007
Highly Cited
2007
24S‐hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis
Levels of the brain‐specific cholesterol metabolite 24S‐hydroxycholesterol are proposed as possible biomarkers for multiple… 
Review
2007
Review
2007
Cholesterol efflux as a critical component of Alzheimer’s disease pathogenesis
The risk of Alzheimer’s disease and the levels of amyloid deposition are altered by factors associated with high cholesterol… 
2007
2007
Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese
2005
2005
CYP46: A risk factor for Alzheimer's disease or a coincidence?
2004
2004
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer’s disease
Review
2004
Review
2004
Genetic Association of CYP46 and Risk for Alzheimer’s Disease
An increasing number of studies suggest that cholesterol plays an important role in regulating beta-amyloid (Aβ) metabolism in… 
Review
2003
Review
2003
Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease.
Highly Cited
2002
Highly Cited
2002
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
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