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Cytochrome P450 Family 46

Known as: Cytochrome P-450 CYP46, Cytochrome P450 Family 46 [Chemical/Ingredient], Cytochrome P 450 CYP46 
A cytochrome P450 enzyme family that includes CHOLESTEROL 24-HYDROXYLASE, which is expressed primarily in the brain and functions in CHOLESTEROL… 
National Institutes of Health

Related topics

Related topics

10 relations
CYP46A1 geneIn BloodProcess of secretionantagonists & inhibitors

Narrower (1)

cholesterol 24-hydroxylase

Papers overview

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Review
2014
Review
2014
Cholesterol metabolism and homeostasis in the brain
Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life… 
Review
2012
Review
2012
Cytochrome P450 (CYP) in fish.
Highly Cited
2003
Highly Cited
2003
Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism.
BACKGROUND CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby… 
Highly Cited
2003
Highly Cited
2003
Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
Highly Cited
2002
Highly Cited
2002
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia.
Highly Cited
2002
Highly Cited
2002
Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
Cholesterol and 24S-hydroxycholesterol are involved in the pathogenesis of Alzheimer's disease (AD). Increased serum cholesterol… 
Highly Cited
2001
Highly Cited
2001
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.
The major cholesterol oxidation products in the human circulation are 27-hydroxycholesterol, 24-hydroxycholesterol, and 7alpha… 
Highly Cited
2001
Highly Cited
2001
On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Review
2000
Review
2000
Regulation of cytochrome P450 (CYP) genes by nuclear receptors.
Members of the nuclear-receptor superfamily mediate crucial physiological functions by regulating the synthesis of their target… 
Highly Cited
1999
Highly Cited
1999
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an… 
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