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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
Several mutations in the amyloid precursor protein (APP) gene have been found to associate with pathologic deposition of the β‐amyloid peptide (Aβ) in neuritic plaques or in the walls of cerebralExpand
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Lipoprotein receptor–mediated induction of matrix metalloproteinase by tissue plasminogen activator
Although thrombolysis with tissue plasminogen activator (tPA) is a stroke therapy approved by the US Food and Drug Administration, its efficacy may be limited by neurotoxic side effects. Recently,Expand
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Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
An increased prevalence of apolipoprotein E (ApoE) epsilon 4 allele exists in late onset familial Alzheimer's disease. We found, in sporadic Alzheimer's disease, that 62% of patients possessed anExpand
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LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
The secreted form of beta-amyloid precursor protein (APP) containing the Kunitz proteinase inhibitor (KPI) domain, also called protease nexin II, is internalized and degraded by cells. We show thatExpand
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Clinical manifestations of cerebral amyloid angiopathy–related inflammation
To explore the clinical effects of inflammation associated with vascular deposits of the amyloid β peptide (Aβ), we analyzed 42 consecutive patients with pathologically diagnosed cerebral amyloidExpand
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Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein
Both apolipoprotein E and its receptor, the low‐density‐lipoprotein receptor‐related protein (LRP), are associated with senile plaques in Alzheimer's disease. We examined the relationship of otherExpand
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Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein*
Cerebral amyloid β-protein angiopathy (CAA) is a key pathological feature of patients with Alzheimer's disease and certain related disorders. In these conditions the CAA is characterized by theExpand
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Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the
Amyloid-β, the major constituent of senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein (APP) by proteolysis. Kunitz protease inhibitor (KPI) containing forms of APPExpand
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Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy.
Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the amyloid beta-peptide, leading to intracerebral hemorrhage in severe cases. Other than rare familial cases, theExpand
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Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
Inheritance of the apolipoprotein E (apoE) ε4 allele is associated with a high likelihood of developing Alzheimer's disease (AD). The pathophysiologic basis of this genetic influence is unknown. WeExpand
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